Cited 0 times in
만성 B형 간염환자에서 간탄력도 측정에 의한 간섬유화의 비침습적 평가
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이근호 | - |
dc.contributor.author | 김화숙 | - |
dc.contributor.author | 전재윤 | - |
dc.contributor.author | 명성민 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 백용한 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 윤기태 | - |
dc.contributor.author | 이관식 | - |
dc.date.accessioned | 2014-12-21T17:28:50Z | - |
dc.date.available | 2014-12-21T17:28:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1738-9364 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97670 | - |
dc.description.abstract | Background: Transient elastography (FibroScan(R)) is a rapid and non-invasive method to measure liver stiffness and this allow the assessment of liver fibrosis. The aim of this study was to assess the diagnostic accuracy of measuring the liver stiffness in addition to measuring the other biochemical markers such as the aspartate transaminase to platelet ratio index [APRI] and the AST/ALT ratio. Methods: We enrolled 228 HBsAg positive patients whose liver stiffness was measured by FibroScan(R) between March 2005 and September 2005. Liver biopsy examinations were performed in 34 patients. The fibrosis (F) was staged on a 0-4 scale according to the Ludwig classification. Results: According to the clinical diagnosis, the median values of liver stiffness were 7.0±2.7 kPa for inactive carriers (n=29), 8.3±5.3 kPa for chronic hepatitis patients (n=106), 15.9±8.3 kPa for compensated cirrhosis patients (n=63), 31.8±20.3 kPa for decompensated cirrhosis patients (n=26), and 45.1±34.5 kPa for HCC patients (n=4). The degree of liver stiffness was significantly different between the different disease groups (p<0.001). Liver stiffness was well correlated with the fibrosis stages (r=0.726; p< 0.001). The AUROC of FibroScan(R), the APRI and the AST/ALT ratio values were of the same order; 0.72, 0.61 and 0.58, respectively, for F≥2; 0.92, 0.73, and 0.56, respectively, for F≥3; and 0.97, 0.79, and 0.55, respectively, for F=4. FibroScan(R) offered the best diagnostic performance both for significant fibrosis (F≥2) and severe fibrosis-cirrhosis (F3-F4). Conclusions: FibroScan(R) is a reliable, rapid non-invasive method to diagnose the severity of chronic liver disease and to predict fibrosis in patients with chronic hepatitis B, in addition to using the APRI and AST/ALT ratio. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 459~469 | - |
dc.relation.isPartOf | Korean Journal of Medicine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 만성 B형 간염환자에서 간탄력도 측정에 의한 간섬유화의 비침습적 평가 | - |
dc.title.alternative | Non-invasive assessment of liver fibrosis by measuring the liver stiffness and biochemical markers in chronic hepatitis B patients | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute of Gastroenterology (소화기병연구소) | - |
dc.contributor.googleauthor | 김화숙 | - |
dc.contributor.googleauthor | 김자경 | - |
dc.contributor.googleauthor | 박영년 | - |
dc.contributor.googleauthor | 명성민 | - |
dc.contributor.googleauthor | 방미선 | - |
dc.contributor.googleauthor | 윤기태 | - |
dc.contributor.googleauthor | 이근호 | - |
dc.contributor.googleauthor | 백용한 | - |
dc.contributor.googleauthor | 이관식 | - |
dc.contributor.googleauthor | 안상훈 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.googleauthor | 문영명 | - |
dc.contributor.googleauthor | 한광협 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02691 | - |
dc.contributor.localId | A01197 | - |
dc.contributor.localId | A01350 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01829 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A02544 | - |
dc.contributor.localId | A02666 | - |
dc.contributor.localId | A03544 | - |
dc.relation.journalcode | J02059 | - |
dc.contributor.alternativeName | Lee, Keun Ho | - |
dc.contributor.alternativeName | Kim, Hwa Sook | - |
dc.contributor.alternativeName | Chon, Chae Yoon | - |
dc.contributor.alternativeName | Myung, Sung Min | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Yoon, Ki Tae | - |
dc.contributor.alternativeName | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Lee, Keun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hwa Sook | - |
dc.contributor.affiliatedAuthor | Myung, Sung Min | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Paik, Yong Han | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Yoon, Ki Tae | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Sik | - |
dc.contributor.affiliatedAuthor | Chon, Chae Yoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 72 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 469 | - |
dc.identifier.bibliographicCitation | Korean Journal of Medicine, Vol.72(5) : 459-469, 2007 | - |
dc.identifier.rimsid | 45878 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.