Cited 10 times in
Bone marrow mononuclear stem cells transplanted in rat enfarct myocardium improved the electrical conduction without evidence of proarrhythmic effects
DC Field | Value | Language |
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dc.contributor.author | 김성순 | - |
dc.contributor.author | 김일권 | - |
dc.contributor.author | 유경종 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.date.accessioned | 2014-12-21T17:25:01Z | - |
dc.date.available | 2014-12-21T17:25:01Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97550 | - |
dc.description.abstract | PURPOSE: The arrhythmogenic effect of stem cells transplantation (SCT) in an infarct myocardium is still unknown. We investigated arrhythmogenicity of SCT in rat cryo-infarct model. MATERIALS AND METHODS: In rat cryo-infarct model, bone marrow mononuclear stem cells (MNSC, 1 x 10(7) cells) were transplanted into the infarct border zone (BZ) of the LV epicardium. We compared the optical mapping and inducibility of ventricular tachycardia/fibrillation (VT/VF) among normal (n=5), cryo-infarct (n=6), and SCT rats (n=6). RESULTS: The VT/VF inducibility was higher in the cryo- infarct (47.2%, p=0.001) and SCT groups (34.6%, p=0.01) than in the normal group (12.8%). The induced VT/VF episodes persisted for more than 2 minutes in 4.3%, 26.4% and 17.3% in the normal, cryo-infarct and SCT group, respectively. In the SCT group, the action potential duration at 70% was shorter at the SCT site than the BZ during SR (75.2 +/- 8.1 vs. 145.6 +/- 4.4 ms, p=0.001) and VT (78.2 +/- 13.0 vs. 125.7 +/- 21.0 ms, p= 0.001). Conduction block was observed at the SCT site and BZ during VT. However, no reentry or ectopic foci were observed around the SCT sites. CONCLUSION: The electrical conduction was improved by SCT without evidence of augmentation of arrhythmia in the rat cryo-infarct model. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 754~764 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bone marrow mononuclear stem cells transplanted in rat enfarct myocardium improved the electrical conduction without evidence of proarrhythmic effects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Il-kwon Kim | - |
dc.contributor.googleauthor | Sung-Soon Kim | - |
dc.contributor.googleauthor | Kyung-Jong Yoo | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.identifier.doi | 10.3349/ymj.2007.48.5.754 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00573 | - |
dc.contributor.localId | A02453 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A00848 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.contributor.alternativeName | Kim, Sung Soon | - |
dc.contributor.alternativeName | Kim, Il Kwon | - |
dc.contributor.alternativeName | Yoo, Kyung Jong | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Sung Soon | - |
dc.contributor.affiliatedAuthor | Yoo, Kyung Jong | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Il Kwon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 754 | - |
dc.citation.endPage | 764 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.48(5) : 754-764, 2007 | - |
dc.identifier.rimsid | 57441 | - |
dc.type.rims | ART | - |
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