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Pleomorphic adenocarcinoma of the lacrimal gland with multiple intracranial and spinal metastases

Authors
 Jung Yong Ahn  ;  Jong Hee Chang  ;  Kyu Sung Lee  ;  Se Hoon Kim 
Citation
 WORLD JOURNAL OF SURGICAL ONCOLOGY, Vol.5 : 29, 2007 
Journal Title
 WORLD JOURNAL OF SURGICAL ONCOLOGY 
Issue Date
2007
Abstract
BACKGROUND: Pleomorphic adenoma of the lacrimal gland is known to undergo malignant transformation when incompletely excised. Even if such a malignant change occurs, intracranial direct invasion and leptomeningeal seeding are seldom encountered. CASE PRESENTATION: A 50-year-old woman presented with malignant transformation associated with both intracranial invasion and multiple intracranial and spinal disseminations in the third recurrence of pleomorphic adenoma of the lacrimal gland, 6 years after initial treatment. MRI demonstrated increased extent of orbital mass, extending to the cavernous sinus. The patient underwent intensity-modulated radiation therapy (IMRT) and Gamma Knife radiosurgery. Follow-up MRI showed multiple leptomeningeal disseminations to the intracranium and spine. CONCLUSION: It is important to recognize that leptomeningeal intracranial and spinal disseminations of pleomorphic adenocarcinoma can occur, although it is extremely rare. To our knowledge, we report the first case of pleomorphic adenocarcinoma of the lacrimal gland presumably metastasizing to the intracranium and spine.
Files in This Item:
T200701309.pdf Download
DOI
10.1186/1477-7819-5-29
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Ahn, Jung Yong(안정용)
Lee, Kyu Sung(이규성)
Chang, Jong Hee(장종희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97451
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