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소아 천식에서 Transforming Growth Factor-β1 Promoter 유전자의 다형성

Other Titles
 Transforming Growth Factor-β1 Promoter Polymorphism in Childhood Asthma 
 박준영  ;  송태원  ;  김규언  ;  손명현  ;  김은수  ;  김경원 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.17(3) : 226-233, 2007 
Journal Title
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지) 
Issue Date
Purpose: The -509C/T polymorphism of the transforming growth factor (TGF)-β1 gene has been associated with asthma and atopy. We evaluate whether TGF-β1 promoter polymorphism (-509C/T) is associated with the asthma phenotype and the development of atopy in Korean children. Methods: We enrolled 278 patients with atopic asthma, 54 non-atopic asthma and 248 healthy children. They underwent through pulmonary function tests and methacholine challenge tests with their eosinophil counts of blood, total serum IgE levels and serum eosinophil cationic protein levels. TGF-β1 promoter polymorphism was genotyped using PCR-restriction fragment length polymorphism (RFLP) assays. Results: No significant difference was observed in allele and genotype frequencies of TGF-β1 -509C/T polymorphism between the patients with atopic asthma or non-atopic asthma and control subjects. Any pulmonary function or atopic variables were not associated with this polymorphism. Furthermore, we showed that -509C/T polymorphism was not associated with bronchial hyperresponsiveness. Conclusion: These results suggest that the -509C/T polymorphism of the TGF-β1 promoter gene may not be associated with bronchial asthma or atopic variables in Korean children.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Eun Soo(김은수)
Park, Jun Young(박준영)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Song, Tae Won(송태원)
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