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Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor

Authors
 Soo-A. Kim  ;  Sang-Gun Ahn  ;  Jung-Hoon Yoon  ;  Jin Kim  ;  Sang-Ho Lee  ;  Joo-Cheol Park  ;  Su-Gwan Kim 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.103(1) : 97-101, 2007 
Journal Title
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 
ISSN
 1079-2104 
Issue Date
2007
Abstract
Dentinogenic ghost cell tumor (DGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). beta-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with DGCT contains a missense mutation on codon 3 (ACT --> TCT) of beta-catenin gene. Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of beta-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that beta-catenin plays an important role in the tumorigenesis of DGCT. DGCT may develop by an improper differentiation process coordinated by Wnt signaling pathway. Further studies are needed to determine the genotypic/phenotypic characteristics of ghost cell-containing odontogenic lesions.
Full Text
http://www.sciencedirect.com/science/article/pii/S1079210405009121
DOI
10.1016/j.tripleo.2005.10.037
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97252
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