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Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy

DC Field Value Language
dc.contributor.author김희진-
dc.contributor.author박현도-
dc.contributor.author이민정-
dc.contributor.author이승일-
dc.contributor.author정한성-
dc.contributor.author조성원-
dc.date.accessioned2014-12-21T17:15:27Z-
dc.date.available2014-12-21T17:15:27Z-
dc.date.issued2007-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/97245-
dc.description.abstractOBJECTIVE: Temporomandibular disorder (TMD) includes a number of clinical conditions involving the masticatory musculature or the temporomandibular joint (TMJ) and associated structures. Previous studies have shown the presence of high-affinity estrogen receptors in the TMJ articular cartilage. The aim of this study was to evaluate the developmental changes in mouse TMJ under estrogen deficiency. MATERIALS AND METHODS: Four-month-old ovariectomized mice were killed after certain weeks. We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy. Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage. In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy. BSP immunoreactivity, however, increased slightly at 2 weeks but then decreased gradually. CONCLUSIONS: Estrogen plays important roles in the metabolism and maintenance of TMJ via regulations of signaling molecules such as BMP-4, Runx2, and BSP. Our results suggest that estrogen deficiency is a candidate cause of TMD. This study revealed further osteogenetic properties of estrogen that may be useful in the clinical treatment and prevention of TMD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent220~227-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAlteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorH-J Min-
dc.contributor.googleauthorM-J Lee-
dc.contributor.googleauthorH-S Jung-
dc.contributor.googleauthorH-J Kim-
dc.contributor.googleauthorS-I Lee-
dc.contributor.googleauthorH-D Park-
dc.contributor.googleauthorS-W Cho-
dc.contributor.googleauthorJ-Y Kim-
dc.identifier.doi10.1111/j.1601-0825.2006.01270.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01225-
dc.contributor.localIdA01735-
dc.contributor.localIdA02924-
dc.contributor.localIdA03758-
dc.contributor.localIdA03837-
dc.contributor.localIdA02785-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2006.01270.x/abstract-
dc.contributor.alternativeNameKim, Hee Jin-
dc.contributor.alternativeNamePark, Hyun Do-
dc.contributor.alternativeNameLee, Min Jung-
dc.contributor.alternativeNameLee, Syng Ill-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthorKim, Hee Jin-
dc.contributor.affiliatedAuthorPark, Hyun Do-
dc.contributor.affiliatedAuthorLee, Syng Ill-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.contributor.affiliatedAuthorCho, Sung Won-
dc.contributor.affiliatedAuthorLee, Min Jung-
dc.rights.accessRightsnot free-
dc.citation.volume13-
dc.citation.number2-
dc.citation.startPage220-
dc.citation.endPage227-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.13(2) : 220-227, 2007-
dc.identifier.rimsid57828-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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