Cited 14 times in
Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy
DC Field | Value | Language |
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dc.contributor.author | 김희진 | - |
dc.contributor.author | 박현도 | - |
dc.contributor.author | 이민정 | - |
dc.contributor.author | 이승일 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2014-12-21T17:15:27Z | - |
dc.date.available | 2014-12-21T17:15:27Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97245 | - |
dc.description.abstract | OBJECTIVE: Temporomandibular disorder (TMD) includes a number of clinical conditions involving the masticatory musculature or the temporomandibular joint (TMJ) and associated structures. Previous studies have shown the presence of high-affinity estrogen receptors in the TMJ articular cartilage. The aim of this study was to evaluate the developmental changes in mouse TMJ under estrogen deficiency. MATERIALS AND METHODS: Four-month-old ovariectomized mice were killed after certain weeks. We examined the significant alterations of the expression patterns of bone morphogenetic protein (BMP)-4, Runx2, and bone sialoprotein (BSP) after ovariectomy. Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage. In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy. BSP immunoreactivity, however, increased slightly at 2 weeks but then decreased gradually. CONCLUSIONS: Estrogen plays important roles in the metabolism and maintenance of TMJ via regulations of signaling molecules such as BMP-4, Runx2, and BSP. Our results suggest that estrogen deficiency is a candidate cause of TMD. This study revealed further osteogenetic properties of estrogen that may be useful in the clinical treatment and prevention of TMD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 220~227 | - |
dc.relation.isPartOf | ORAL DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | H-J Min | - |
dc.contributor.googleauthor | M-J Lee | - |
dc.contributor.googleauthor | H-S Jung | - |
dc.contributor.googleauthor | H-J Kim | - |
dc.contributor.googleauthor | S-I Lee | - |
dc.contributor.googleauthor | H-D Park | - |
dc.contributor.googleauthor | S-W Cho | - |
dc.contributor.googleauthor | J-Y Kim | - |
dc.identifier.doi | 10.1111/j.1601-0825.2006.01270.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01225 | - |
dc.contributor.localId | A01735 | - |
dc.contributor.localId | A02924 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03837 | - |
dc.contributor.localId | A02785 | - |
dc.relation.journalcode | J02438 | - |
dc.identifier.eissn | 1601-0825 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2006.01270.x/abstract | - |
dc.contributor.alternativeName | Kim, Hee Jin | - |
dc.contributor.alternativeName | Park, Hyun Do | - |
dc.contributor.alternativeName | Lee, Min Jung | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Kim, Hee Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyun Do | - |
dc.contributor.affiliatedAuthor | Lee, Syng Ill | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Lee, Min Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 227 | - |
dc.identifier.bibliographicCitation | ORAL DISEASES, Vol.13(2) : 220-227, 2007 | - |
dc.identifier.rimsid | 57828 | - |
dc.type.rims | ART | - |
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