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Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma

Authors
 So-Yeon Park  ;  Seoung-Ae Lee  ;  Sung-Weon Choi  ;  Jin Kim  ;  In-Ho Cha  ;  Jo-Yong Park  ;  Seung-Hoon Lee  ;  Byong-Chul Yoo  ;  In-Hee Han 
Citation
 ONCOLOGY REPORTS, Vol.17(1) : 81-87, 2007 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
2007
Abstract
The multifunctional G-protein-coupled metabotropic glutamate receptor (mGluR) family comprises eight subtypes, some of which participate in tumorigenesis. The purpose of this study was to evaluate mGluR5 expression in oral squamous cell carcinoma (SCC) tissues and oral cancer cell lines. We also investigated the prognostic significance of mGluR5 and its functional importance in the migration, invasion, and adhesion of oral cancer cells. We evaluated the expression of mGluR5 in samples from 131 oral SCC patients and in several oral cancer cell lines by immunohistochemistry and RT-PCR. We observed varying levels of mGluR5 in human oral SCC tissues and cancer cell lines. There was a significant association between strong mGluR5 immunoreactivity and overall survival (P=0.0109). The functional significance of the expression of mGluR5 in oral cancer cells was then investigated in HSC3 oral tongue cancer cells. An mGluR5 agonist, DHPG increased tumor cell migration, invasion, and adhesion in HSC3 cells (P<0.05). This was reversed by the mGluR5 antagonist MPEP. Our results strongly suggest that mGluR5 is a new prognostic marker and contributes to tumor cell migration and invasion in oral cancer.
Full Text
http://www.spandidos-publications.com/or/17/1/81
DOI
10.3892/or.17.1.81
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97227
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