Cited 42 times in
Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability
DC Field | Value | Language |
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dc.contributor.author | 김재환 | - |
dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2014-12-21T17:13:06Z | - |
dc.date.available | 2014-12-21T17:13:06Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97169 | - |
dc.description.abstract | During endochondral ossification, a process that accounts for the majority of bone formation in vertebrates, hypertrophic chondrocytes display a greater susceptibility to apoptosis when compared to proliferating chondrocytes. However, the molecular mechanisms underlying this phenomenon remain unclear. Nkx3.2, a member of the NK class of homeoproteins, is initially expressed in chondrogenic precursor cells, and later, during cartilage maturation, its expression is restricted to proliferating chondrocytes. Here, we show that the nuclear factor kappa B (NF-kappaB) pathway is required for chondrocyte viability and that Nkx3.2 supports chondrocyte survival by constitutively activating RelA. Although signal-dependent NF-kappaB activation has been intensively studied, ligand-independent NF-kappaB activation is poorly understood. The data presented here support a novel ligand-independent mechanism of NF-kappaB activation, whereby Nkx3.2 recruits the RelA–IkappaBalpha heteromeric complex into the nucleus by direct protein–protein interactions and activates RelA through proteasome-dependent IkappaBalpha degradation in the nucleus. Furthermore, we demonstrate that stage-specific NF-kappaB activation, mediated by Nkx3.2, regulates chondrocyte viability during cartilage maturation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 287~298 | - |
dc.relation.isPartOf | NATURE CELL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anatomy (해부학) | - |
dc.contributor.googleauthor | Minsun Park | - |
dc.contributor.googleauthor | Yeryoung Yong | - |
dc.contributor.googleauthor | Dae-Won Kim | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Jae Hwan Kim | - |
dc.contributor.googleauthor | Seung-Won Choi | - |
dc.identifier.doi | 10.1038/ncb1538 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00875 | - |
dc.contributor.localId | A03146 | - |
dc.relation.journalcode | J02291 | - |
dc.identifier.eissn | 1476-4679 | - |
dc.identifier.url | http://www.nature.com/ncb/journal/v9/n3/full/ncb1538.html | - |
dc.contributor.alternativeName | Kim, Jae Hwan | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 287 | - |
dc.citation.endPage | 298 | - |
dc.identifier.bibliographicCitation | NATURE CELL BIOLOGY, Vol.9(3) : 287-298, 2007 | - |
dc.identifier.rimsid | 55220 | - |
dc.type.rims | ART | - |
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