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Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 이종두 | - |
dc.date.accessioned | 2014-12-21T17:09:01Z | - |
dc.date.available | 2014-12-21T17:09:01Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97040 | - |
dc.description.abstract | Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 113~119 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jae Goo Kim | - |
dc.contributor.googleauthor | Min Soo Kim | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Gun Tae Kim | - |
dc.contributor.googleauthor | Seoul Lee | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A03138 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 119 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.11(3) : 113-119, 2007 | - |
dc.identifier.rimsid | 53621 | - |
dc.type.rims | ART | - |
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