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영아에서 진단된 다발성 부정형세포조직구증 1예

Other Titles
 A Case of Indeterminate Cell Histiocytosis in an Infant 
Authors
 김남균  ;  최성열  ;  유철주  ;  원성철  ;  한정우  ;  권승연  ;  이광길 
Citation
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양), Vol.14(2) : 221-225, 2007 
Journal Title
 Clinical Pediatric Hematology-Oncology (임상소아혈액종양) 
ISSN
 2233-5250 
Issue Date
2007
Abstract
Indeterminate cell histiocytosis is a rare disease of predominant cells having features that resemble both Langerhans cells and macrophages. The cells have greater pleomorphism with polyobated nuclei and these cells express markers for macrophages and Langerhans cells such as CD1a and S-100 protein, but absent Birbeck granules. We report a case of multiple indeterminate cell histiocytosis in a 3-month-old infant. He presents multiple reddish-brown, slightly yellowish papules on forehead, ear, shoulder, abdomen, testis and legs since 2 months earlier. The lesions were nonpruritic and painless with varied diameters of 2 mm to 2 cm. Immunohistochemically, the examination of biopsy revealed positive for macrophage marker (CD68) as well as for Langerhans cell markers such as S-100 protein and CD1a. No Birbeck granules were seen ultrastructurally in the cytoplasm of cells by electron microscopic study. So, it was confirmed as indeterminate cell histiocytosis. As we know, it is the first case in Korea which developed in neonatal period.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97022
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