70 176

Cited 3 times in

Investigation of von Willebrand factor gene mutations in Korean von Willebrand disease patients

Other Titles
 한국 von Willebrand병 환자의 von Willebrand 인자 유전자 돌연변이 조사 
Authors
 Jaewoo Song  ;  Jong Rak Choi  ;  Kyung Soon Song 
Citation
 Korean Journal of Laboratory Medicine, Vol.27(3) : 169-176, 2007 
Journal Title
 Korean Journal of Laboratory Medicine 
ISSN
 1598-6535 
Issue Date
2007
Abstract
BACKGROUND: We intended to find the mutations of von Willebrand factor (VWF) gene as the most important contributing factor of von Willebrand disease (VWD) in Korean patients. METHODS: In 40 known vWD patients mutations of vWF gene were sought by direct sequencing of PCR products targeting exons 18, 19, 20, 26, 28 and 52 frequently implicated as the locations of mutation. For factors other than VWF gene contributing to VWD phenotype, we tested ABO blood group and measured ADAMTS13 activity in VWD patients. RESULTS: Twenty-seven cases (67.5%) were type 1 vWD, 3 cases (7.5%) type 3, and 5 cases (12.5%) type 2A. Three cases were type 2A or 2B (7.5%) and 2 cases were suspected to be type 2N (5.0%). Among them six candidate missense mutations were found: V1279I, R1306W, R1308C, and V1316M were previously reported in type 2B and type 1 vWD, and C858W and T1477I were novel findings. All patients were heterozygotes. Blood group O was overly represented in VWD patients, while ADAMTS13 activity of the patients was not significantly different from that of normal control. CONCLUSIONS: Mutation of VWF gene detected by genetic studies can significantly improve the diagnostic accuracy, especially in subtype assignment of VWD. Two novel mutations, C858W and T1477I associated with VWD were found and expected to contribute to the elucidation of its pathophysiology.
Files in This Item:
T200700424.pdf Download
DOI
10.3343/kjlm.2007.27.3.169
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
송경순(Song, Kyung Soon)
송재우(Song, Jae Woo)
최종락(Choi, Jong Rak) ORCID logo https://orcid.org/0000-0002-0608-2989
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96948
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse