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골수형성이상증후군에서의 임상진료지침

Other Titles
 The Clinical Guidelines for Myelodysplastic Syndrome 
Authors
 박찬정  ;  정준원  ;  김선희  ;  민유홍  ;  한경자  ;  조빈  ;  조덕연  ;  정철원  ;  이홍기  ;  원종호  ;  윤성수  ;  안진석  ;  박현진  ;  김형준  ;  김인호  ;  주영돈  ;  이제환  ;  방수미  ;  국훈 
Citation
 Korean Journal of Hematology, Vol.42(2) : 71-90, 2007 
Journal Title
 Korean Journal of Hematology 
ISSN
 1738-7949 
Issue Date
2007
Abstract
The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis associated with multilineage cytopenias leading to serious morbidity or mortality, and the additional risk of leukemic transformation. The management of patients with MDS can be very complex and varies according to both the clinical manifestations in individual patients as well as the presence of complicating medical conditions. However, therapeutic dilemmas still exist for MDS due to the multifactorial pathogenetic features of the disease, its heterogeneous stages, and the elderly patient population. For these reasons, proper guidelines for management are necessary. This review describes the proper diagnosis for MDS, decision-making approaches for optimal therapeutic options that are based on a consideration of patient clinical factors and risk-based prognostic categories, and the use of recently available biospecific drugs such as hypomethylating agents that are potentially capable of abrogating the abnormalities associated with MDS. Proper indications and methods for transplantation, response criteria, management for iron overload for highly transfused patients and specific considerations for MDS in childhood are also described. All of these topics were discussed at the third symposium of AML/MDS working party on 3 March, 2007.
Files in This Item:
T200700015.pdf Download
DOI
10.5045/kjh.2007.42.2.71
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96936
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