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제2형 당뇨병 환자에서 인슐린저항성 지표와 프레밍험 위험도와의 관련성

Other Titles
 The association between insulin resistance and Framingham risk score among type 2 diabetes 
Authors
 박희숙  ;  윤지은  ;  지선하  ;  허갑범  ;  이은직  ;  조미애  ;  최영주  ;  송영득  ;  김대중  ;  안철우  ;  박석원  ;  안경아  ;  조어린  ;  윤수진 
Citation
 Korean Journal of Epidemiology (한국역학회지), Vol.29(1) : 46-58, 2007 
Journal Title
 Korean Journal of Epidemiology (한국역학회지) 
ISSN
 1225-3596 
Issue Date
2007
Abstract
Background and purpose: Insulin resistance has been known to be associated with the risk of cardiovascular diseases. However, the relationship with Framingham risk score among type 2 diabetes has not been well known. We investigated the relationship between insulin resistance (IR) and the Framingham risk score(FRS) among type 2 diabetes in Korea. Methods: We estimated the 5-year risk of ischemic heart disease(IHD) based on Framingham equation among 1,941 diabetes patients(1,294 men and 647 women), who visited Huh"s clinic, enrolled from January 2003 to June 2006. IR, which was measured by insulin tolerance test (ITT), was divided into five groups(Q1 to Q5). High risk of IHD was defined as upper 10 percentile of FRS. Multivariate regression and logistic regression models were used to see independent association of higher quintiles of IR level, compared with lowest quintile(Q1) for the risk of IHD. Results: Mean (±standard deviation) 5-year FRS of study subjects were 8.40%(±6.89) for men and 5.92%(±5.23) for women. There were significant correlation between IR, body mass index, HbA1C, fasting glucose, triglyceride, LDL-cholesterol, C-peptide and FRS in both men and women. After adjusting for triglyceride, LDL-cholesterol, C-peptide, multivariate regression model analysis showed that IR was independently associated with the FRS. A positive association between IR and high risk of IHD was observed in men: highest versus lowest quintile of IR (odds ratio 5.45 in men and 4.71 in women). Conclusion: Increased IR level was independently associated with risk of IHD measured by FRS among type 2 diabetes in Korea.
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Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yun, Soo Jin(윤수진)
Yun, Ji Eun(윤지은)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Cho, Mi Ae(조미애)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96894
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