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Activation of the renin–angiotensin system within podocytes in diabetes

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author곽승재-
dc.contributor.author김주성-
dc.contributor.author김진주-
dc.contributor.author김형종-
dc.contributor.author유태현-
dc.contributor.author이금희-
dc.contributor.author이정은-
dc.contributor.author정동섭-
dc.contributor.author최훈영-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.date.accessioned2014-12-21T17:01:32Z-
dc.date.available2014-12-21T17:01:32Z-
dc.date.issued2007-
dc.identifier.issn0085-2538-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96801-
dc.description.abstractThe autocrine and paracrine activation of the renin-angiotensin system (RAS) within cells of the kidney plays a role in the overall pathophysiology of the renal disease due to diabetes. In this study, we focus on components of the RAS in the podocyte as these cells are important in the pathogenesis of glomerulosclerosis and proteinuria. Immortalized mouse podocytes were exposed to media containing normal glucose (NG) or high glucose (HG) for in vitro studies. In vivo studies utilized kidney tissue obtained from rats treated for 3 months with streptozotocin to induce diabetes. Angiotensinogen (AGT) and the angiotensin II (AII) type 1 receptor mRNA and protein were significantly increased in the podocytes cultured under the high glucose conditions. Both angiotensins I and II levels were significantly higher in cell lysates and the conditioned media of cells grown in high glucose. There were no differences in renin activity, angiotensin-converting enzyme level, or AII type 2 receptor level. Glomerular AGT and AII type 1 receptor assessed by means of immunohistochemistry were increased in diabetic rats compared with the control rats. Other measured components of the RAS within the glomeruli were not different. We suggest that increased AGT, an attendant increase in AII and increased AII type 1 receptor in podocytes experiencing diabetic conditions play an important role in the pathogenesis of diabetic nephropathy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1019~1027-
dc.relation.isPartOfKIDNEY INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleActivation of the renin–angiotensin system within podocytes in diabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorT-H Yoo-
dc.contributor.googleauthorJ-J Li-
dc.contributor.googleauthorS-W Kang-
dc.contributor.googleauthorD S Han-
dc.contributor.googleauthorJ E Lee-
dc.contributor.googleauthorS H Han-
dc.contributor.googleauthorH J Kim-
dc.contributor.googleauthorJ S Kim-
dc.contributor.googleauthorH Y Choi-
dc.contributor.googleauthorD-R Ryu-
dc.contributor.googleauthorS-J Kwak-
dc.contributor.googleauthorD-S Jung-
dc.contributor.googleauthorJ-J Kim-
dc.identifier.doi10.1038/sj.ki.5002195-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00170-
dc.contributor.localIdA00934-
dc.contributor.localIdA01029-
dc.contributor.localIdA01155-
dc.contributor.localIdA02526-
dc.contributor.localIdA02692-
dc.contributor.localIdA03594-
dc.contributor.localIdA04226-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.contributor.localIdA03119-
dc.relation.journalcodeJ01941-
dc.identifier.eissn1523-1755-
dc.identifier.urlhttp://www.kidney-international.org/article/S0085-2538(15)56125-5/abstract-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKwak, Seung Jae-
dc.contributor.alternativeNameKim, Joo Sung-
dc.contributor.alternativeNameKim, Jin Ju-
dc.contributor.alternativeNameKim, Hyung Jong-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLi, Jin Ji-
dc.contributor.alternativeNameLee, Jung Eun-
dc.contributor.alternativeNameJung, Dong Sub-
dc.contributor.alternativeNameChoi, Hoon Young-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKwak, Seung Jae-
dc.contributor.affiliatedAuthorKim, Joo Sung-
dc.contributor.affiliatedAuthorKim, Jin Ju-
dc.contributor.affiliatedAuthorKim, Hyung Jong-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorLi, Jin Ji-
dc.contributor.affiliatedAuthorJung, Dong Sub-
dc.contributor.affiliatedAuthorChoi, Hoon Young-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.rights.accessRightsnot free-
dc.citation.volume71-
dc.citation.number10-
dc.citation.startPage1019-
dc.citation.endPage1027-
dc.identifier.bibliographicCitationKIDNEY INTERNATIONAL, Vol.71(10) : 1019-1027, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers

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