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Matrix Metalloproteinase Expression in the Recurrence of Superficial Low Grade Bladder Transitional Cell Carcinoma

Authors
 Young Deuk Choi  ;  Nam Hoon Cho  ;  Won Jae Yang  ;  Soung Yong Cho  ;  Kang Su Cho  ;  Hyun Soo Ahn 
Citation
 JOURNAL OF UROLOGY, Vol.177(3) : 1174-1178, 2007 
Journal Title
 JOURNAL OF UROLOGY 
ISSN
 0022-5347 
Issue Date
2007
MeSH
Aged ; Carcinoma, Transitional Cell/metabolism* ; Carcinoma, Transitional Cell/pathology ; Case-Control Studies ; Female ; Humans ; Male ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism* ; Middle Aged ; Neoplasm Recurrence, Local/metabolism* ; Proto-Oncogene Proteins c-fos/metabolism ; RNA, Messenger/metabolism ; Transforming Growth Factor beta/metabolism ; Urinary Bladder Neoplasms/metabolism* ; Urinary Bladder Neoplasms/pathology ; Vascular Endothelial Growth Factor A/metabolism
Abstract
PURPOSE: Superficial bladder transitional cell carcinoma has a high recurrence rate following endoscopic resection. Most parameters used to predict recurrence are associated with high grade transitional cell carcinoma. However, there are few valid parameters for predicting low grade transitional cell carcinoma recurrence. We elucidated the prime factor in recurrent superficial low grade bladder transitional cell carcinoma. MATERIALS AND METHODS: A total of 40 cases of superficial low grade bladder transitional cell carcinoma were analyzed, including 20 recurrent and 20 nonrecurrent cases. Fresh frozen tumor and normal tissues were used. Real-time reverse transcriptase-polymerase chain reaction and Western blots were performed subsequently to evaluate the validity of molecules identified by 0.12K cDNA array composed of matrix metalloproteinase, oncogenes and cell cycle related genes. RESULTS: On cDNA microarray analysis matrix metalloproteinase-1, 2, 9, 12 and 15, transforming growth factor-beta1, vascular endothelial growth factor and fos were found to be significantly up-regulated in recurrent cases. On real-time reverse transcriptase-polymerase chain reaction to validate those molecules matrix metalloproteinase-1 and 12, transforming growth factor-beta1, vascular endothelial growth factor and fos were significantly over expressed in recurrent cases. Western blot showed significant over expression of matrix metalloproteinase-1 and 12, transforming growth factor-beta1, vascular endothelial growth factor and fos in recurrent cases. CONCLUSIONS: Over expression of matrix metalloproteinase-1 and 12, transforming growth factor-beta1, vascular endothelial growth factor and fos may be associated with the recurrence of superficial low grade bladder transitional cell carcinoma.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534706027698
DOI
10.1016/j.juro.2006.10.031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yang, Won Jae(양원재)
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Cho, Soung Yong(조성용)
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96719
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