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What is the best treatment modality for adrenal metastasis from hepatocellular carcinoma?

 Joon Seong Park  ;  Dong Sup Yoon  ;  Byong Ro Kim  ;  Hoon Sang Chi  ;  Woo Jung Lee  ;  Jin Sub Choi  ;  Kyung Sik Kim 
 JOURNAL OF SURGICAL ONCOLOGY, Vol.96(1) : 32-36, 2007 
Journal Title
Issue Date
Adrenal Gland Neoplasms/mortality ; Adrenal Gland Neoplasms/secondary* ; Adrenal Gland Neoplasms/therapy* ; Adrenalectomy* ; Adult ; Aged ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/secondary* ; Chemoembolization, Therapeutic* ; Combined Modality Therapy ; Female ; Hepatectomy ; Humans ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology* ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate
PURPOSE: This study aimed to analyze the effect of each therapeutic modality to clarify the treatment strategy for adrenal metastases from hepatocellular carcinoma (HCC). METHODS: Adrenal metastasis from HCC was observed in 45 patients. Fifteen patients who were determined to have multi-organ metastasis including the adrenal glands were excluded, and the remaining 30 patients were reviewed. RESULTS: The location of adrenal metastasis was right side, left side, and both in 17, 9, and 4 patients, respectively. Treatment for adrenal metastasis consisted of adrenalectomy in 5 patients, non-surgical treatment such as TACE, or chemotherapy and radiotherapy in 19 patients, while 6 patients received no treatment. The median survival duration was 11.05 months in the 30 patients with adrenal metastasis. In the 25 patients with well-controlled intrahepatic lesions, the median survival time of those patients who received adrenalectomy, non-surgical treatment, and no treatment was 21.41, 11.05, and 5.64 months, respectively. The difference in cumulative survival according to mode of treatment of adrenal metastasis in the well-controlled intrahepatic lesion group was statistically significant. CONCLUSION: We envisage increased benefit after adrenalectomy in terms of survival in patients with well controlled intrahepatic lesions at the time of adrenal metastasis and good general medical condition.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Byong Ro(김병로)
Park, Joon Seong(박준성) ORCID logo https://orcid.org/0000-0001-8048-9990
Yoon, Dong Sup(윤동섭) ORCID logo https://orcid.org/0000-0001-6444-9606
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Chi, Hoon Sang(지훈상)
Choi, Jin Sub(최진섭)
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