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Recurrence after Topical Nonpreserved Methylprednisolone Therapy for Keratoconjunctivitis Sicca in Sjögren's Syndrome

DC FieldValueLanguage
dc.contributor.author김응권-
dc.contributor.author서경률-
dc.contributor.author정소향-
dc.contributor.author홍사민-
dc.date.accessioned2014-12-21T16:51:57Z-
dc.date.available2014-12-21T16:51:57Z-
dc.date.issued2007-
dc.identifier.issn1080-7683-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96498-
dc.description.abstractBACKGROUND: The aim of this study was to evaluate the prevalence of long-term recurrence after topical nonpreserved methylprednisolone pulse therapy for the treatment of keratoconjunctivitis sicca (KCS) with Sjögren's syndrome. METHODS: A total of 106 eyes of 53 Sjögren's syndrome patients were included in the study. All patients were treated with topical nonpreserved 1% methylprednisolone solution. Initial therapy consisted of eyedrops 4 times a day for 2 weeks, and then patients were reevaluated and tapered off the medication every 2 weeks until discontinuation. Tear film breakup time (TBUT), Schirmer test, corneal fluorescein staining, and subjective symptom scores were measured. Additionally, impression cytology of the bulbar conjunctiva was performed. The over-all success rates and success period were determined using the Kaplan-Meier survival curve. RESULTS: A reduction in subjective symptoms and fluorescein staining, and an improvement in TBUT and Schirmer test results, was observed after treatment (P<0.001). Impression cytology specimens revealed a significantly increased number of periodic acid-Schiff-positive cells after treatment. After the first pulse therapy, mean survival was 56.6 weeks and 11 (20.8%) patients recurred. After the second pulse therapy, mean survival was 72.4 weeks and only 1 patient recurred. No serious complications, including intraocular pressure elevation and cataract formation, were encountered during the entire follow-up period. CONCLUSIONS: Topical nonpreserved methylprednisolone pulse therapy proved to be a safe, effective long-term treatment of improving subjective and objective dry eye factors in KCS patients with Sjögren's syndrome.-
dc.description.statementOfResponsibilityopen-
dc.format.extent78~82-
dc.relation.isPartOfJOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Topical-
dc.subject.MESHFemale-
dc.subject.MESHGlucocorticoids/administration & dosage*-
dc.subject.MESHHumans-
dc.subject.MESHKeratoconjunctivitis Sicca/drug therapy*-
dc.subject.MESHKeratoconjunctivitis Sicca/etiology-
dc.subject.MESHMale-
dc.subject.MESHMethylprednisolone/administration & dosage*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOphthalmic Solutions/administration & dosage-
dc.subject.MESHPreservatives, Pharmaceutical-
dc.subject.MESHPulse Therapy, Drug-
dc.subject.MESHRecurrence-
dc.subject.MESHSjogren's Syndrome/complications-
dc.subject.MESHSjogren's Syndrome/drug therapy*-
dc.subject.MESHTears/metabolism-
dc.subject.MESHTreatment Outcome-
dc.titleRecurrence after Topical Nonpreserved Methylprednisolone Therapy for Keratoconjunctivitis Sicca in Sjögren's Syndrome-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Ophthalmology (안과학)-
dc.contributor.googleauthorSamin Hong-
dc.contributor.googleauthorTerry Kim-
dc.contributor.googleauthorKyoung Yul Seo-
dc.contributor.googleauthorEung Kweon Kim-
dc.contributor.googleauthorSo-Hyang Chung-
dc.identifier.doi10.1089/jop.2006.0091-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00831-
dc.contributor.localIdA01870-
dc.contributor.localIdA03633-
dc.contributor.localIdA04395-
dc.relation.journalcodeJ01654-
dc.identifier.eissn1557-7732-
dc.identifier.pmid17341155-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/jop.2006.0091-
dc.contributor.alternativeNameKim, Eung Kweon-
dc.contributor.alternativeNameSeo, Kyuong Yul-
dc.contributor.alternativeNameChung, So Hyang-
dc.contributor.alternativeNameHong, Sa Min-
dc.contributor.affiliatedAuthorKim, Eung Kweon-
dc.contributor.affiliatedAuthorSeo, Kyuong Yul-
dc.contributor.affiliatedAuthorChung, So Hyang-
dc.contributor.affiliatedAuthorHong, Sa Min-
dc.rights.accessRightsnot free-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage78-
dc.citation.endPage82-
dc.identifier.bibliographicCitationJOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, Vol.23(1) : 78-82, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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