Cited 17 times in
Lipase-catalyzed acylation of naringin with palmitic acid in highly concentrated homogeneous solutions
DC Field | Value | Language |
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dc.contributor.author | 김현정 | - |
dc.date.accessioned | 2014-12-21T16:51:29Z | - |
dc.date.available | 2014-12-21T16:51:29Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1381-1177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96483 | - |
dc.description.abstract | Acylation reactions of naringin with palmitic acid were performed by a lipase after formation of highly concentrated homogeneous solutions. Their initial naringin concentration was 840–950 mM, which is 20–60 times greater than that in organic solvent media. The overall productivity of highly concentrated solutions was more than 15 times greater than those of organic phase media. The addition of DMSO (20–40%, w/w) to substrate mixtures lowered the melting temperature of a naringin–palmitic acid mixture (1:1 molar ratio) to about 40 °C. Reactions at 80 °C apparently followed Michaelis–Menten kinetics despite extremely high substrate concentrations. As the temperature increased from 60 °C to 80 °C, the apparent viscosity of the highly concentrated solution decreased remarkably from 4.31 Pa s to 0.063 Pa s. An activation energy of 7.65 kcal/mol obtained in a range of 60–75 °C suggests a diffusion-control. On the other hand, an activation energy of 17.09 kcal/mol in a range of 75–90 °C indicates a reaction-control. The highest product conversion yield of 33% (mol/mol) was obtained in a 10 h reaction at 80 °C. Addition of activated molecular sieves to the highly concentrated solution increased the product conversion yield by 7% (mol/mol), suggesting that the original equilibrium was disrupted by removing water and then a new equilibrium was reached. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 26~31 | - |
dc.relation.isPartOf | Journal of Molecular Catalysis B-Ensymatic | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lipase-catalyzed acylation of naringin with palmitic acid in highly concentrated homogeneous solutions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Sung Hun Youn | - |
dc.contributor.googleauthor | Hyun Jung Kim | - |
dc.contributor.googleauthor | Chul Soo Shin | - |
dc.contributor.googleauthor | Tae Han Kim | - |
dc.identifier.doi | 10.1016/j.molcatb.2007.02.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01131 | - |
dc.relation.journalcode | J01604 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1381117707000410 | - |
dc.contributor.alternativeName | Kim, Hyun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 1-4 | - |
dc.citation.startPage | 26 | - |
dc.citation.endPage | 31 | - |
dc.identifier.bibliographicCitation | Journal of Molecular Catalysis B-Ensymatic, Vol.46(1-4) : 26-31, 2007 | - |
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