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부갑상선기능저하증을 동반한 Kearns-Sayre Syndrome 환아에서 Coenzyme Q10 복용으로 고칼슘혈증이 유발된 사례 1례

Other Titles
 A Case of the Hypercalcemia Induced by the Coenzyme Q10 and Alphacalcidol Treatment in a Patient with Kearns-Sayre Syndrome and Hypoparathyroidism 
Authors
 정현희  ;  김덕희  ;  황현희 
Citation
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.12(2) : 155-158, 2007 
Journal Title
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지) 
ISSN
 1226-2242 
Issue Date
2007
Keywords
Kearns-Sayre syndrome ; hypoparathyroidism ; serum calcium concentration ; alfacalcidol (1α-OHD3) ; Coenzyme Q10
Abstract
Kearns-Sayre Syndrome (KSS) is rare mitochondrial disorder characterized by chronic progressive external ophthalmoplegia, atypical retinal pigmentation and complete heart block. It is occasionally combined endocrinologic symptoms such as hypoparathyroidism, short stature, diabetes mellitus and hypothyroidism. We reported the effect of Coenzyme Q10 on total serum calcium concentration in 17 years old girl with KSS and hypoparathyroidism. The patients was treated with alfacalcidol (1α-OHD3), Coenzyme Q10 and oral calcium agent. Total serum calcium concentration had even remained within normal range and hypercalcemia was developed suddenly after treatment of combination of Coenzyme Q10 and alfacalcidol (1α-OHD3). After stop of all medication, her total calcium concentration was decreased to 7.6 mg/dL and remained in normal range with oral calcium (2 g/day) and Coenzyme Q10 (150 mcg/day) daily. The action of Coenzyme Q10 is not clearly defined but, we could explain Coenzyme Q10 activates the capacity of the patient to produce the active form of Vitamin D, 1alpha-OHD3.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96451
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