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경막외 Naloxone 투여가 경막외 Sufentanil에 의한 가려움증에 미치는 영향

Other Titles
 Effects of Epidural Naloxone on Pruritus Induced by Epidural Sufentanil 
 임의성  ;  김기준  ;  공명훈  ;  남순호  ;  윤주선 
 KOREAN JOURNAL OF PAIN, Vol.20(2) : 123-129, 2007 
Journal Title
Issue Date
naloxone ; patient controlled analgesia ; pruritus ; sufentanil
Background Postoperative pruritus following the administration of epidural narcotics is a very common and undesirable side effect. Therefore, we evaluated the use of a combination of naloxone and sufentanil via patient controlled epidural analgesia to determine if the incidence of pruritus was decreased when compared to the use of sufentanil alone. Methods Patients scheduled for subtotal gastrectomy under general anesthesia were enrolled in a prospective, double-blinded and randomized trial. All patients received a 20 µg epidural bolus of sufentanil in 5 ml of 0.2% ropivacaine. Following administration of the epidural, patients in the sufentanyl group (S) received a continuous epidural comprised of sufentanil (0.75 µg/ml) in 0.2% ropivacaine, whereas patients in the naloxone group (N) received an epidural infusion comprised of naloxone (4 µg/ml) and sufentanil (0.75 µg/ml) in 0.2% ropivacaine. The infusion rate, demand dose and lockout interval were 5 ml/hr, 0.5 ml and 15 minutes respectively. Next, the occurrence of postoperative analgesia and side effects were evaluated by blinded observers. Results The incidence of pruritus (47.4% versus 20.0%, P = 0.013) and nausea (42.1% versus 20.0%, P = 0.043) were lower in group N than in group S. In addition, there were no significant differences observed in the visual analogue scale, the incidence of vomiting or the incidence of sedation. Furthermore, epidural infusion of naloxone at 0.25-0.4 µg/kg/hr did not affect the requirement for postoperative sufentanil. Conclusions Epidural naloxone reduces epidural sufentanil induced pruritus and nausea without reversing its analgesic effects.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Jun(김기준) ORCID logo https://orcid.org/0000-0003-1950-7998
Nam, Soon Ho(남순호)
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