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Lesion of Subthalamic Nucleusin Parkinsonian Rats :Effects of Dopamine D1 and D2 ReceptorAgonists on the Neuronal Activitiesof the Substantia Nigra Pars Reticulata

 Yong Sook Park  ;  Mi Fa Jeon  ;  Jin Woo Chang  ;  Bae Hwan Lee 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.42(6) : 455-461, 2007 
Journal Title
Journal of Korean Neurosurgical Society(대한신경외과학회지)
Issue Date
6-hydroxydopamine ; Substantia nigra pars reticulate ; Kainic acid ; Subthalamic nucleus ; Dopamine agonist ; Parkinson's disease
Objective It was hypothesized that dopamine agonist administration and subthalamic nucleus (STN) lesion in the rat might have a synergistic effect on the neuronal activities of substantia nigra pars reticulata (SNpr) as observed in patients with Parkinson's disease. The effects of SKF38393 (a D1 receptor agonist) and Quinpirole (a D2 receptor agonist) were compared in parkinsonian rat models with 6- hydroxydopamine (6-OHDA) after STN lesion. Methods SKF38393 and Quinpirole were consecutively injected intrastriatally. SNpr was microrecorded to ascertain the activity of the basal ganglia output structure. The effect of SKF38393 or Quinpirole injection on the firing rate and firing patterns of SNpr was investigated in medial forebrain bundle (MFB) lesioned rats and in MFB+STN lesioned rats. Results The administration of SKF38393 decreased SNpr neuronal firing rates and the percentage of burst neurons in the MFB lesioned rats, but did not alter them in MFB+STN lesioned rats. The administration ofQuinpirole significantly decreased the spontaneous firing rate in the MFB lesioned rats. However, after an additional STN lesion, it increased the percentage of burst neurons. Conclusion This study demonstrated that dopamine agonists and STN lesion decreased the hyperactive firing rate and the percentage of burst neurons of SNpr neurons in 6-OHDA lesioned rats, respectively. Quinpirole with STN lesion increased a percentage of burst neurons. To clear the exact interactive mechanism of D1 and D2 agonist and the corresponding location, it should be followed a study using a nonselective dopamine agonist and D1, D2 selective antagonist.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
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