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Changes in Serum Adenosine Deaminase Activity during Normal Pregnancy

Authors
 Soo Jin Lee  ;  Han Sung Hwang  ;  Young Han Kim  ;  Yong Won Park  ;  Jae Wook Lee  ;  Min A Kim  ;  Bit Na Rae Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.22(4) : 718-721, 2007 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2007
Abstract
Adenosine deaminase (ADA), an enzyme essential for the differentiation of lymphoid cells, has been used for monitoring diseases with altered immunity. The purpose of this study was to investigate the changes in serum ADA activity throughout normal pregnancy. We measured the catalytic values of serum ADA from 202 normal pregnant women using a commercial kit. Subjects were divided into four groups according to the gestational age in weeks (Gwks) (Group I: 5-9 Gwks [n=58]; Group II: 15-20 Gwks [n= 63]; Group III: 24-30 Gwks [n=34]; Group IV: 30-39 Gwks [n=47]). The serum ADA levels for the Groups I, II, III, and IV were as follows: 20.1±6.9 IU/L, 20.0±7.6 IU/L, 37.9±19.9 IU/L, and 24.5±8.6 IU/L, respectively. The serum ADA activity of group III was significantly higher than the other groups (p<0.05). However, there was no significant correlation between the Gwks and the serum ADA activity. Furthermore, other parameters, such as maternal age (p=0.29), gestational age at delivery (p=0.07), delivery mode (p=0.39), and birth weight (p=0.59) had no correlation with ADA activity. Reference values of serum ADA in normal pregnancy may provide important database for making clinical decisions in pregnancies complicated by conditions where cellular immunity has been altered.
Files in This Item:
T200700499.pdf Download
DOI
10.3346/jkms.2007.22.4.718
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Han(김영한) ORCID logo https://orcid.org/0000-0003-0645-6028
Park, Yong Won(박용원)
Hwang, Han Sung(황한성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96407
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