4 236

Cited 70 times in

Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes

Authors
 Seung-Soon Im  ;  Sool-Ki Kwon  ;  Yong-Ho Ahn  ;  Ha-il Kim  ;  Tae-Hyun Kim 
Citation
 IUBMB LIFE, Vol.59(3) : 134-145, 2007 
Journal Title
 IUBMB LIFE 
ISSN
 1521-6543 
Issue Date
2007
MeSH
Adipocytes/physiology* ; Amino Acid Sequence ; Animals ; Gene Expression Regulation* ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism* ; Humans ; Molecular Sequence Data ; Muscles/physiology* ; Promoter Regions, Genetic ; Protein Isoforms/genetics ; Protein Isoforms/metabolism* ; Sequence Alignment ; Sequence Analysis, Protein
Keywords
Glucose transporter type 4 isoform ; promoter (GLUT4) ; transcriptional factors ; insulin resistance ; cis-element ; trans-acting factors.
Abstract
The gene expression of glucose transporter type 4 isoform (GLUT4) is known to be controlled by metabolic, nutritional, or hormonal status. Understanding the molecular mechanisms governing GLUT4 gene expression is critical, because glucose disposal in the body depends on the activities of GLUT4 in the muscle and adipocytes. The GLUT4 activities are regulated by a variety of mechanisms. One of them is transcriptional regulation. GLUT4 gene expression is regulated by a variety of transcriptional factors in muscle and adipose tissue. These data are accumulating regarding the transcriptional factors regulating GLUT4 gene expression. These include MyoD, MEF2A, GEF, TNF-α, TR-1α, KLF15, SREBP-1c, C/EBP-α, O/E-1, free fatty acids, PAPRγ, LXRα, NF-1, etc. These factors are involved in the positive or negative regulation of GLUT4 gene expression. In addition, there is a complex interplay between these factors in transactivating GLUT4 promoter activity. Understanding the mechanisms controlling GLUT4 gene transcription in these tissues will greatly promote the potential therapeutic drug development for obesity and T2DM.
Full Text
http://onlinelibrary.wiley.com/doi/10.1080/15216540701313788/abstract
DOI
10.1080/15216540701313788
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Sool Ki(권슬기)
Kim, Tae Hyun(김태현)
Kim, Ha Il(김하일)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
Im, Seung Soon(임승순)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96209
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse