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The significance of c-erbB-2 overexpression and p53 expression in patients with axillary lymph node-negative breast cancer: A tissue microarray study

Authors
 Seung-Sang Ko  ;  Youn-Sun Na  ;  Jee-Hyun Lee  ;  Byeong-Woo Park  ;  Sung-Soo Kang  ;  Yi-Kyung Chun  ;  Hae-Kyung Lee  ;  Min-Hee Hur  ;  Hye-Sun Kim  ;  Ji-Young Park  ;  Chan-Seok Yoon 
Citation
 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, Vol.15(2) : 98-109, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY 
ISSN
 1066-8969 
Issue Date
2007
MeSH
Adult ; Axilla ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/metabolism* ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/pathology ; Combined Modality Therapy ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Immunoenzyme Techniques ; Lymph Nodes ; Lymphatic Metastasis ; Middle Aged ; Prognosis ; Receptor, ErbB-2/metabolism* ; Retrospective Studies ; Survival Rate ; Tissue Array Analysis ; Tumor Suppressor Protein p53/metabolism*
Keywords
breast cancer ; c-erbB-2 ; p53 ; microarray ; survival ; prognosis
Abstract
We conducted this study to examine whether the expression of c-erbB-2 and p53 is the prognostic indicator for patients with early-stage breast cancer in which axillary lymph node metastasis is absent. We examined 326 patients with early-stage breast cancer in which axillary lymph node metastasis is absent. Tissue microarrays were constructed. Following this, immunohistochemical staining was done for estrogen receptor (ER), progesterone receptor (PR), c-erbB2, and p53. The results were as follows: (1) expression of c-erbB-2 was correlated with other clinicopathologic factors (eg, patient's age, presence of menopause, tumor size, histologic and nuclear grade, and presence of hormone receptors such as ER and PR); and (2) expression of p53 was correlated with survival rate, patient's age, presence of menopause, and tumor size. However, these results were not statistically significant. In conclusion, our results indicate that expression of c-erbB-2 and p53 did not have any prognostic value in patients with early-stage breast cancer in which axillary lymph node metastasis is absent.
Full Text
http://ijs.sagepub.com/content/15/2/98.long
DOI
10.1177/1066896906299124
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96197
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