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Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment

Authors
 Byung Soh Min  ;  Nam Kyu Kim  ;  Seung Kook Sohn  ;  Chang Hwan Cho  ;  Seung Hyuk Baek  ;  Kang Young Lee  ;  Yong Taek Ko 
Citation
 INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, Vol.22(11) : 1325-1330, 2007 
Journal Title
 INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 
ISSN
 0179-1958 
Issue Date
2007
MeSH
Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Radiotherapy,Adjuvant ; Rectal Neoplasms/pathology ; Rectal Neoplasms/prevention & control ; Rectal Neoplasms/radiotherapy* ; Rectal Neoplasms/surgery* ; Recurrence ; Time Factors ; Treatment Outcome
Keywords
Local excision ; Rectal cancer ; Adjuvant treatment ; Abdominoperineal resection
Abstract
AIM: The aim of this study is to review long-term oncologic results of local excision (LE) and to investigate the validity and feasibility of LE as a treatment option for distal rectal cancer. MATERIALS AND METHODS: Seventy-six patients who underwent LE for distal rectal adenocarcinoma with curative intent from 1991 to 2000 at Severance Hospital Yonsei University Medical Center, Seoul, Korea were enrolled in this study. RESULTS: Preoperative transrectal ultrasonography revealed 3 cases of uT0, 55 cases of uT1 and 18 cases of uT2. Postoperative pathologic examination revealed 10 cases of pT0 (where no residual cancer cells remained), 11 cases of pTis, 37 cases of pT1, 16 cases of pT2, and 2 cases of pT3. Eleven out of 37 patients with pT1 tumors received adjuvant radiation therapy. Among 16 patients with pT2 tumor, 7 undertook salvage operation and 8 received adjuvant therapy. The median follow-up period was 84.9 months. Local recurrence was observed in six patients. The 5-year local recurrence-free survival rate (LFS) was 89.4% in the pT1 group and 75.0% in the pT2 group (p = 0.012). Among the patients with pT1 cancer, those who received adjuvant radiation therapy demonstrated a 5-year LFS of 100%, compared to those who did not, 76.0% (p = 0.038). CONCLUSION: Our results imply a potential role of LE and adjuvant radiation as an option for the treatment of distal rectal cancer, and that even for pT1 carcinoma, LE alone might not be a valid modality. PMID: 17571241 [PubMed - indexed for MEDLINE]
Full Text
http://link.springer.com/article/10.1007%2Fs00384-007-0339-2
DOI
10.1007/s00384-007-0339-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Yong Taek(고용택)
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Baik, Seung Hyuk(백승혁) ORCID logo https://orcid.org/0000-0003-4183-2332
Sohn, Seung Kook(손승국)
Lee, Kang Young(이강영)
Cho, Chang Hwan(조장환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96154
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