Cited 15 times in
Sequence Polymorphisms of Major German Cockroach Allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5
DC Field | Value | Language |
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dc.contributor.author | 정경용 | - |
dc.contributor.author | 홍천수 | - |
dc.contributor.author | 용태순 | - |
dc.contributor.author | 이명희 | - |
dc.contributor.author | 이해석 | - |
dc.date.accessioned | 2014-12-21T16:40:12Z | - |
dc.date.available | 2014-12-21T16:40:12Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96126 | - |
dc.description.abstract | BACKGROUND: The allergenicity of allergens could be influenced by amino acid substitutions in B- or T-cell epitope regions. The German cockroach is known to produce potent allergens inducing strong IgE-mediated allergic reactions. This study was performed to investigate sequence variations in major allergens of the German cockroach. METHODS: Reverse transcriptase PCR was used to amplify the cDNA sequences encoding major allergens of the German cockroach (Bla g 1, Bla g 2, Bla g 4, and Bla g 5). RESULTS: The deduced amino acid sequences revealed 38 Bla g 1 variants with 1-7 amino acid substitutions (98.6-99.8% identity), 28 Bla g 2 variants with 1-3 substitutions (99.1-99.7%), 27 Bla g 4 variants with 0-32 substitutions (82.4-100%), and 8 Bla g 5 variants with 1-2 substitutions (99.0-99.5%), respectively. Bla g 1 and Bla g 2 showed sporadic amino acid substitutions despite the divergence in their sequences. Bla g 4 exhibited frequent variations, with clusters of substitutions in residues 29-38, 52-80, and 132-155. Sequence variations in Bla g 4 imply the presence of multiple isoforms and isoallergens, which may in turn have various effects on the IgE-binding capacity and T-cell responsiveness. Only 8 variants were found in Bla g 5, with infrequent amino acid changes of one or two residues. CONCLUSIONS: Analyses of T-cell and IgE-binding epitope regions would clarify the effect of sequence polymorphisms on allergenicity, which in turn will aid in the design of allergen formulations for diagnosis and immunotherapy for cockroach allergies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~8 | - |
dc.relation.isPartOf | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Allergens/genetics* | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cockroaches/genetics* | - |
dc.subject.MESH | Cockroaches/immunology | - |
dc.subject.MESH | DNA, Complementary/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Insect Proteins/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Polymorphism, Genetic | - |
dc.subject.MESH | Sequence Alignment | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.title | Sequence Polymorphisms of Major German Cockroach Allergens Bla g 1, Bla g 2, Bla g 4, and Bla g 5 | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute of Allergy (알레르기연구소) | - |
dc.contributor.googleauthor | Kyoung Yong Jeong | - |
dc.contributor.googleauthor | Haeseok Lee | - |
dc.contributor.googleauthor | Tai-Soon Yong | - |
dc.contributor.googleauthor | Chein-Soo Hong | - |
dc.contributor.googleauthor | Kyoung-jin Jeong | - |
dc.contributor.googleauthor | Myung-hee Yi | - |
dc.contributor.googleauthor | Kwang Hyun Shin | - |
dc.identifier.doi | 10.1159/000107460 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03572 | - |
dc.contributor.localId | A02424 | - |
dc.contributor.localId | A02761 | - |
dc.contributor.localId | A03281 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J01074 | - |
dc.identifier.eissn | 1423-0097 | - |
dc.identifier.pmid | 17703094 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/107460 | - |
dc.contributor.alternativeName | Jeong, Kyoung Yong | - |
dc.contributor.alternativeName | Hong, Chein Soo | - |
dc.contributor.alternativeName | Yong, Tai Soon | - |
dc.contributor.alternativeName | Yi, Myung Hee | - |
dc.contributor.alternativeName | Lee, Hae Seok | - |
dc.contributor.affiliatedAuthor | Jeong, Kyoung Yong | - |
dc.contributor.affiliatedAuthor | Yong, Tai Soon | - |
dc.contributor.affiliatedAuthor | Yi, Myung Hee | - |
dc.contributor.affiliatedAuthor | Lee, Hae Seok | - |
dc.contributor.affiliatedAuthor | Hong, Chein Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 145 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, Vol.145(1) : 1-8, 2007 | - |
dc.identifier.rimsid | 35448 | - |
dc.type.rims | ART | - |
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