3 558

Cited 28 times in

Insulin resistance is associated with arterial stiffness independent of obesity in male adolescents

DC Field Value Language
dc.contributor.author심재용-
dc.contributor.author이덕철-
dc.contributor.author이지원-
dc.contributor.author이혜리-
dc.date.accessioned2014-12-21T16:39:31Z-
dc.date.available2014-12-21T16:39:31Z-
dc.date.issued2007-
dc.identifier.issn0916-9636-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/96104-
dc.description.abstractTo determine the relationship between insulin resistance (IR) and arterial stiffness independent of obesity in male adolescents, we evaluated body fat, lipid parameters, indices of IR (fasting insulin, and the homeostasis model assessment of insulin resistance [HOMA-IR]), indices of insulin sensitivity (IS) (fasting glucose/fasting insulin [GF/IF], and the quantitative insulin sensitivity check index [QUICKI]), and lifestyle parameters in 256 male adolescents. We divided the study group into the following four subgroups based on the median value of HOMA-IR and obesity: non-obese with IS, non-obese with IR, obese with IS, and obese with IR. In order to estimate arterial stiffness, we measured brachial ankle pulse wave velocity (baPWV). Despite having a high body mass index (BMI), obese-IS adolescents showed a significantly lower fasting insulin and baPWV, but had higher IS indices than non-obese-IR adolescents. After an adjustment for age, BMI, waist-to-hip ratio, mean blood pressure, heart rate, total cholesterol level, triglyceride, alanine aminotransferase (ALT) level, physical activity, and television and computer usage, multiple regression models showed that baPWV was independently correlated with IR and IS indices. In conclusion, our results demonstrate an association between IR and baPWV independent of weight, suggesting that IR is a risk factor for the development of early atherosclerosis. Interventions that decrease IR in addition to weight reduction may be necessary to alter the early development of cardiovascular risk.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5~11-
dc.relation.isPartOfHYPERTENSION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHArteries/physiopathology*-
dc.subject.MESHAtherosclerosis/etiology-
dc.subject.MESHBlood Flow Velocity-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBody Weight-
dc.subject.MESHElasticity-
dc.subject.MESHFasting/blood-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/blood-
dc.subject.MESHInsulin Resistance*-
dc.subject.MESHMale-
dc.subject.MESHObesity/physiopathology-
dc.subject.MESHPulse-
dc.subject.MESHRisk Factors-
dc.titleInsulin resistance is associated with arterial stiffness independent of obesity in male adolescents-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorJi-Won Lee-
dc.contributor.googleauthorDuk-Chul Lee-
dc.contributor.googleauthorHye-Ree Lee-
dc.contributor.googleauthorSang-Man Kim-
dc.contributor.googleauthorJae-Yong Shim-
dc.contributor.googleauthorJee-Aee Im-
dc.identifier.doi10.1291/hypres.30.5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02207-
dc.contributor.localIdA02716-
dc.contributor.localIdA03310-
dc.contributor.localIdA03203-
dc.relation.journalcodeJ01017-
dc.identifier.eissn1348-4214-
dc.identifier.pmid17460366-
dc.identifier.urlhttp://www.nature.com/hr/journal/v30/n1/full/hr20073a.html-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameLee, Hye Ree-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Duk Chul-
dc.contributor.affiliatedAuthorLee, Hye Ree-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.rights.accessRightsnot free-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPage5-
dc.citation.endPage11-
dc.identifier.bibliographicCitationHYPERTENSION RESEARCH, Vol.30(1) : 5-11, 2007-
dc.identifier.rimsid35435-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.