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Effect of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy

Authors
 Young Tae Kim  ;  Sang Wun Kim  ;  Jae Wook Kim  ;  Jae Hoon Kim  ;  Sung Hoon Kim  ;  Eun Ji Nahm  ;  Hye Jin Cho  ;  Bo Sung Yoon 
Citation
 GYNECOLOGIC ONCOLOGY, Vol.105(1) : 199-204, 2007 
Journal Title
GYNECOLOGIC ONCOLOGY
ISSN
 0090-8258 
Issue Date
2007
MeSH
Adult ; Aged ; Anemia/etiology ; Anemia/prevention & control* ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Cisplatin/adverse effects ; Cisplatin/therapeutic use ; Combined Modality Therapy ; Female ; Ferric Compounds/therapeutic use* ; Ferric Oxide, Saccharated ; Glucaric Acid ; Humans ; Middle Aged ; Prospective Studies ; Uterine Cervical Neoplasms/blood* ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/therapy*
Abstract
OBJECTIVE:
The incidence of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy is estimated to be more than 50%. Transfusion has been the mainstay of hematologic support with its inherent hazards including infection and transfusion reaction. The aim of this study was to examine the impact of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients undergoing concurrent chemoradiotherapy.
METHODS:
From Oct. 2003 to Dec. 2005, 75 patients were treated with platinum-based concurrent chemoradiotherapy. Thirty patients received 200 mg of iron sucrose intravenously (study group) and 45 patients did not receive it (control group).
RESULTS:
In the study group, only 12 (40.0%) patients required blood transfusions, whereas 29 (64.0%) patients in the control group needed blood transfusions (P=0.04). Mean transfusion units were 1.87 units in the study group and 3.58 units in the control group (P=0.04).
CONCLUSION:
This study showed that intravenous supply of iron sucrose could decrease transfusion requirement and increase serum hemoglobin level in patients with cervical carcinoma undergoing concurrent chemoradiotherapy. Therefore, intravenously administered iron sucrose would be effective in the prevention of anemia of cervical cancer patients receiving concurrent chemoradiotherapy.
Full Text
http://www.sciencedirect.com/science/article/pii/S0090825806009292
DOI
10.1016/j.ygyno.2006.11.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Yoon, Bo Sung(윤보성)
Cho, Hye Jin(조혜진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96070
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