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The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance

 Eun Ji Nam  ;  Jae Wook Kim  ;  Sunghoon Kim  ;  Nam Hoon Cho  ;  Bo Sung Yoon  ;  Jae Hoon Kim  ;  Young Tae Kim  ;  Sang Wun Kim 
 GYNECOLOGIC ONCOLOGY, Vol.104(1) : 207-211, 2007 
Journal Title
Issue Date
Alphapapillomavirus/classification ; Alphapapillomavirus/isolation & purification ; Cervical Intraepithelial Neoplasia/metabolism* ; Cervical Intraepithelial Neoplasia/pathology ; Cervical Intraepithelial Neoplasia/virology ; Cyclin-Dependent Kinase 4/biosynthesis ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Female ; Humans ; Immunohistochemistry ; Papillomavirus Infections/complications ; Papillomavirus Infections/metabolism ; Paraffin Embedding ; Predictive Value of Tests ; Prognosis ; Retinoblastoma Protein/biosynthesis* ; Retinoblastoma Protein/metabolism ; Uterine Cervical Neoplasms/metabolism* ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
The aim of the study was to assess the expression of the Rb pathway (p16(INK4a)-cdk4-pRb) in cervical intraepithelial neoplasia as a prognostic marker by investigating the association between expression of Rb pathway and the recurrence.
The study group comprised of 265 paraffin-embedded tissues of the uterine cervix collected from patients between 2001 and 2003. Patients underwent ablative or excisional treatment and were followed for 2 years. RB pathway expression was examined using immunohistochemistry applied to a tissue microarray. HPV detection and genotyping were performed with HPV DNA Chip. Statistical analysis was done by ANOVA test, Student's t test, and Pearson's correlation test.
With increasing CIN grade, p16(INK4a) and cdk4 expression rates increased, while the pRb expression rate decreased. The expression rate of p16(INK4a) was higher (33%) in CIN I with high-risk HPV infection than in CIN I without high-risk HPV infection (19%). The mean expression rates of p16(INK4a) were 29%, 39%, and 64%, respectively, in CIN I, II, and III without recurrence, but 25%, 28%, and 44% in those with recurrence. The mean expression rates of pRb were 47%, 40%, and 18% in CIN I, II, and III without recurrence, respectively, but 48%, 45%, and 34% in those with recurrence.
A relatively low expression rate of p16(INK4a) has prognostic significance for predicting recurrence. The clinical utility of p16(INK4a) status for stratifying patients according to their need for aggressive treatment requires further investigation.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sang Wun(김상운) ORCID logo https://orcid.org/0000-0002-8342-8701
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Young Tae(김영태) ORCID logo https://orcid.org/0000-0002-7347-1052
Kim, Jae Wook(김재욱)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Nam, Eun Ji(남은지) ORCID logo https://orcid.org/0000-0003-0189-3560
Yoon, Bo Sung(윤보성)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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