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Using proteomics to identify targets of antiendothelial cell antibodies

Authors
 Ju Hee Lee  ;  Mi Ryung Roh  ;  Kwang Hoon Lee  ;  Dongsik Bang 
Citation
 EXPERT REVIEW OF CLINICAL IMMUNOLOGY, Vol.3(6) : 983-991, 2007 
Journal Title
 EXPERT REVIEW OF CLINICAL IMMUNOLOGY 
ISSN
 1744-666X 
Issue Date
2007
Abstract
Antiendothelial cell antibodies represent a heterogeneous group of antibodies directed against a variety of antigen determinants of endothelial cells. Antibodies reacting with endothelial structures have been detected in sera from patients with autoimmune vasculitis, both primary and secondary to systemic connective tissue diseases. It may interfere with several functions and, therefore, may be a pathophysiological relevance. The analysis of the antigens recognized by antiendothelial cell antibodies showed that the antibodies are directed against a heterogeneous family of both constitutive and nonconstitutive surface endothelial proteins. Proteomics is a field of science that evaluates a large number of proteins expressed from a given cell line or organism. The technology of proteomics has been used as a method for discovering the target protein specific to a particular disease by searching for the expression or modification of the protein. Recently, progress has been made in defining the target antigens of these antibodies and proteomic technologies is one of them. This review will focus on the proteomic technologies in searching autoantigens/autoantibodies associated with disease of the endothelium.
Full Text
http://informahealthcare.com/doi/abs/10.1586/1744666X.3.6.983
DOI
10.1586/1744666X.3.6.983
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Bang, Dong Sik(방동식)
Lee, Kwang Hoon(이광훈)
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/96034
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