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Disturbed surround inhibition in preclinical parkinsonism

Authors
 Hae-Won Shin  ;  Suk Y. Kang  ;  Young H. Sohn 
Citation
 CLINICAL NEUROPHYSIOLOGY, Vol.118(10) : 2176-2179, 2007 
Journal Title
 CLINICAL NEUROPHYSIOLOGY 
ISSN
 1388-2457 
Issue Date
2007
Abstract
OBJECTIVE: Surround inhibition in the motor system is an essential mechanism for selective execution of desired movements. To evaluate the functional operation of surround inhibition in Parkinson disease, we performed a transcranial magnetic stimulation (TMS) study in the asymptomatic hands of hemiparkinsonism patients. METHODS: TMS was set to be triggered by self-initiated flexion of the index finger at different intervals from 3 to 2000 ms. Average motor evoked potential (MEP) amplitudes obtained from self-triggered TMS were normalized to average MEPs of control TMS at rest. Normalized MEP amplitudes of the patients' self-triggered TMS sessions at different intervals were compared to those of the controls. RESULTS: During index finger flexion, MEP amplitudes from the little finger muscle were unchanged in normal subjects. However, they were enhanced in Parkinson patients, despite the absence of any motor disturbance. CONCLUSIONS: These results suggest that the functional operation of surround inhibition is impaired in Parkinson disease. This disturbance may precede motor disturbance in Parkinson disease. SIGNIFICANCE: Impaired surround inhibition can be useful to detect preclinical parkinsonism.
Full Text
http://www.sciencedirect.com/science/article/pii/S1388245707003288
DOI
10.1016/j.clinph.2007.06.058
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Suk Yun(강석윤)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Shin, Hye Won(신혜원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95887
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