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한국인 정상 성인에서의 작고 조밀한 저밀도 지단백과 죽상경화증, 인슐린 저항성과의 연관성

Other Titles
 Relationship of Small Dense LDL to Atherosclerosis and Insulin Resistance in Korean Healthy Adults 
 조민호  ;  정한영  ;  이현철  ;  김경래  ;  임승길  ;  차봉수  ;  안철우  ;  강은석  ;  박종숙  ;  김혜진  ;  남지선  ;  윤지은 
 Clinical Diabetes (임상당뇨병), Vol.8(1S) : 37-47, 2007 
Journal Title
 Clinical Diabetes (임상당뇨병) 
Issue Date
Background: The measurement of low density lipoprotein (LDL) particle size has a possibility of a predictor for atherosclerosis. The aim of this study is to investigate the relationship of LDL particle size to carotid intima-media thickness (IMT), the levels of insulin resistance and oxidative stress in healthy Korean adults. Methods: The subjects were total 99 who were clinically healthy and without medications that might alter glucose and lipid metabolism. Carotid intima-media thickness was measured by high resolution ultrasonography, mean LDL particle size by electrophoresis, insulin resistance by kitt value of short insulin tolerance test, and oxidative stress by MDA (malondialdehyde) absorption levels. Results: Carotid intima-media thickness was not significant correlated with LDL particle size. LDL particle size was significantly correlated with age, waist circumference, male gender, total cholesterol, triglyceride, HDL cholesterol, HbA1c levels, insulin resistance, and oxidative stress by simple Pearson`s correlation, but the independent predictors of LDL particle size determined by multiple stepwise regression analysis were serum triglyceride, HDL cholesterol level, age, kitt, and oxidative stress. Conclusion: In healthy Korean adults, the best predictors for LDL particle size were serum triglyceride level, HDL cholesterol level, age, insulin resistance and oxidative stress. Small dense LDL was not a predictor of IMT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Kyung Rae(김경래)
Kim, Hae Jin(김혜진)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Lee, Hyun Chul(이현철)
Lim, Sung Kil(임승길)
Cho, Min Ho(조민호)
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
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