Cited 134 times in
Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin
DC Field | Value | Language |
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dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2014-12-21T16:29:26Z | - |
dc.date.available | 2014-12-21T16:29:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95790 | - |
dc.description.abstract | Silibinin, a flavonoid isolated from Silybum marianum, has been reported to have cancer chemopreventive and therapeutic effects. Here, we show that treatment with subtoxic doses of silibinin in combination with tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant glioma cells, but not in human astrocytes, suggesting that this combined treatment may offer an attractive strategy for safely treating gliomas. Although the proteolytic processing of procaspase-3 by TRAIL was partially blocked in glioma cells, cotreatment with silibinin efficiently recovered TRAIL-induced caspase activation in these cells. Silibinin treatment up-regulated DR5, a death receptor of TRAIL, in a transcription factor CHOP-dependent manner. Furthermore, treatment with silibinin down-regulated the protein levels of the antiapoptotic proteins FLIPL, FLIPS, and survivin through proteasome-mediated degradation. Taken together, our results show that the activity of silibinin to modulate multiple components in the death receptor–mediated apoptotic pathway is responsible for its ability to recover TRAIL sensitivity in TRAIL-resistant glioma cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 8274~8284 | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Silibinin Sensitizes Human Glioma Cells to TRAIL-Mediated Apoptosis via DR5 Up-regulation and Down-regulation of c-FLIP and Survivin | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Cancer Research (암연구소) | - |
dc.contributor.googleauthor | Yong-gyu Son | - |
dc.contributor.googleauthor | Eun Hee Kim | - |
dc.contributor.googleauthor | Kyeong Sook Choi | - |
dc.contributor.googleauthor | Chae-Ok Yun | - |
dc.contributor.googleauthor | A-Rum Yoon | - |
dc.contributor.googleauthor | Taeg Kyu Kwon | - |
dc.contributor.googleauthor | Seung U. Kim | - |
dc.contributor.googleauthor | Jin Yeop Kim | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-07-0407 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02614 | - |
dc.relation.journalcode | J00452 | - |
dc.identifier.eissn | 1538-7445 | - |
dc.contributor.alternativeName | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Yun, Chae Ok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 67 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 8274 | - |
dc.citation.endPage | 8284 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, Vol.67(17) : 8274-8284, 2007 | - |
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