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Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice

DC Field Value Language
dc.contributor.author윤채옥-
dc.date.accessioned2014-12-21T16:29:24Z-
dc.date.available2014-12-21T16:29:24Z-
dc.date.issued2007-
dc.identifier.issn0008-5472-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95789-
dc.description.abstractSelective replication of oncolytic viruses in tumor cells provides a promising approach for the treatment of human cancers. One of the limitations observed with oncolytic viruses currently used in the treatment of solid tumors is the inefficient spread of virus throughout the tumor mass following intratumoral injection. Data are presented showing that oncolytic adenoviruses expressing the relaxin gene and containing an Ad5/Ad35 chimeric fiber showed significantly enhanced transduction and increased virus spread throughout the tumor when compared with non–relaxin-expressing, Ad5-based viruses. The increased spread of such viruses throughout tumors correlated well with improved antitumor efficacy and overall survival in two highly metastatic tumor models. Furthermore, nonreplicating viruses expressing relaxin did not increase metastases, suggesting that high level expression of relaxin will not enhance metastatic spread of tumors. In summary, the data show that relaxin may play a role in rearranging matrix components within tumors, which helps recombinant oncolytic adenoviruses to spread effectively throughout the tumor mass and thereby increase the extent of viral replication within the tumor. Expressing relaxin from Ad5/Ad35 fiber chimeric adenoviruses may prove a potent and novel approach to treating patients with cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent4399~4407-
dc.relation.isPartOfCANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRelaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentInstitute for Cancer Research (암연구소)-
dc.contributor.googleauthorShanthi Ganesh-
dc.contributor.googleauthorMelissa Gonzalez Edick-
dc.contributor.googleauthorKarin Jooss-
dc.contributor.googleauthorChae-Ok Yun-
dc.contributor.googleauthorMichael Robinson-
dc.contributor.googleauthorMelinda VanRoey-
dc.contributor.googleauthorMarina Abramova-
dc.contributor.googleauthorNeeraja Idamakanti-
dc.identifier.doi10.1158/0008-5472.CAN-06-4260-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02614-
dc.relation.journalcodeJ00452-
dc.identifier.eissn1538-7445-
dc.contributor.alternativeNameYun, Chae Ok-
dc.contributor.affiliatedAuthorYun, Chae Ok-
dc.rights.accessRightsfree-
dc.citation.volume67-
dc.citation.number9-
dc.citation.startPage4399-
dc.citation.endPage4407-
dc.identifier.bibliographicCitationCANCER RESEARCH, Vol.67(9) : 4399-4407, 2007-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers

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