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Separation of apoptotic cells using a microfluidic device

Authors
 Hyun-Seok Kim  ;  Oh-Taek Son  ;  Hyo-Il Jung  ;  Sunglyul Maeng  ;  Sang-Hyeob Kim  ;  Kun-Hong Kim 
Citation
 BIOTECHNOLOGY LETTERS, Vol.29(11) : 1659-1663, 2007 
Journal Title
 BIOTECHNOLOGY LETTERS 
ISSN
 0141-5492 
Issue Date
2007
Abstract
A highly sensitive microfluidic device has been developed to separate apoptotic cells. Apoptotic Jurkat cells were selectively labeled with magnetic beads (0.8 μm diam) using the C2A protein which recognizes phosphatidylserine. The cell mixture was flowed through a microfluidic channel and apoptotic cells were separated by a 0.3 T permanent magnet. Separations using our device showed 96% agreement with those of a commercial flow cytometer, indicating our device can be used to sort apoptotic cells in a miniaturized system.
Full Text
http://link.springer.com/article/10.1007%2Fs10529-007-9451-1
DOI
10.1007/s10529-007-9451-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kun Hong(김건홍) ORCID logo https://orcid.org/0000-0001-5639-6372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95727
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