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Significant association of C-reactive protein with arterial stiffness in treated non-diabetic hypertensive patients

 Jung-Sun Kim  ;  Tae Soo Kang  ;  Namsik Chung  ;  Yangsoo Jang  ;  Donghoon Choi  ;  Young-Guk Ko  ;  Changsoo Kim  ;  Sungha Park  ;  Hye-Sun Seo  ;  Jin-Bae Kim 
 ATHEROSCLEROSIS, Vol.192(2) : 401-406, 2007 
Journal Title
Issue Date
C-reactive protein (CRP) has been known to be associated with vascular inflammation and hypertension. Pulse wave velocity (PWV) increases according to the degree of the arterial stiffness in hypertension patients. Therefore, PWV may be correlated with CRP levels in treated hypertensive patients, irrespective of medication. We sought to determine whether there is a correlation between hsCRP and arterial stiffness in non-diabetic treated hypertensive patients, independent of cardiovascular risk factor.

This study consisted of 424 non-diabetic patients at least 45-years-old who were being treated for hypertension. At the time of enrollment, the patients underwent a baseline laboratory assessment of C-reactive protein levels and pulse wave velocity (PWV). Heart to femoral PWV (hfPWV) and brachial to ankle PWV (baPWV) were used as a marker of arterial stiffness.

Subjects were categorized according to tertiles of hsCRP level [Group 1: first tertile (0.20–0.46 mg/L), Group 2: second tertile (0.47–1.15 mg/L), Group 3: third tertile (1.17–9.71 mg/L)]. Group 1 consisted of 141 patients (mean age 58 ± 8 years), Group 2 had 142 patients (mean age 60 ± 9 years) and Group 3 had 141 patients (mean age 61 ± 8 years). The hfPWV and baPWV increased significantly along with the hsCRP level. Group 1, Group 2 and Group 3 demonstrated hfPWV and baPWV of 965 ± 199 and 1438 ± 246, 975 ± 174 and 1487 ± 258 and 1043 ± 215 and 1566 ± 252 cm/s, respectively (p < 0.01). The hfPWV also showed a strong correlation with baPWV (r = 0.698, p < 0.001). The hsCRP level was independently associated with arterial stiffness (hfPWV: R2 = 0.273, p < 0.001; baPWV: R2 = 0.284, p = 0.001) after controlling for age, body mass index, systolic blood pressure (BP), heart rate, gender, HDL-cholesterol, triglyceride, glucose level and medications.

In conclusion, hsCRP was associated with arterial stiffness, independent of age, systolic BP, gender, heart rate, glucose, lipid profiles and medications in treated hypertension. Therefore, hsCRP could be a useful marker of arterial stiffness in treated hypertension patients and a possible target for arterial inflammation in hypertension.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Kim, Jin Bae(김진배)
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Seo, Hye Sun(서혜선)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
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