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Significant association of C-reactive protein with arterial stiffness in treated non-diabetic hypertensive patients

DC Field Value Language
dc.contributor.author고영국-
dc.contributor.author김중선-
dc.contributor.author김진배-
dc.contributor.author김창수-
dc.contributor.author박성하-
dc.contributor.author서혜선-
dc.contributor.author장양수-
dc.contributor.author정남식-
dc.contributor.author최동훈-
dc.date.accessioned2014-12-21T16:25:51Z-
dc.date.available2014-12-21T16:25:51Z-
dc.date.issued2007-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/95679-
dc.description.abstractC-reactive protein (CRP) has been known to be associated with vascular inflammation and hypertension. Pulse wave velocity (PWV) increases according to the degree of the arterial stiffness in hypertension patients. Therefore, PWV may be correlated with CRP levels in treated hypertensive patients, irrespective of medication. We sought to determine whether there is a correlation between hsCRP and arterial stiffness in non-diabetic treated hypertensive patients, independent of cardiovascular risk factor. This study consisted of 424 non-diabetic patients at least 45-years-old who were being treated for hypertension. At the time of enrollment, the patients underwent a baseline laboratory assessment of C-reactive protein levels and pulse wave velocity (PWV). Heart to femoral PWV (hfPWV) and brachial to ankle PWV (baPWV) were used as a marker of arterial stiffness. Subjects were categorized according to tertiles of hsCRP level [Group 1: first tertile (0.20–0.46 mg/L), Group 2: second tertile (0.47–1.15 mg/L), Group 3: third tertile (1.17–9.71 mg/L)]. Group 1 consisted of 141 patients (mean age 58 ± 8 years), Group 2 had 142 patients (mean age 60 ± 9 years) and Group 3 had 141 patients (mean age 61 ± 8 years). The hfPWV and baPWV increased significantly along with the hsCRP level. Group 1, Group 2 and Group 3 demonstrated hfPWV and baPWV of 965 ± 199 and 1438 ± 246, 975 ± 174 and 1487 ± 258 and 1043 ± 215 and 1566 ± 252 cm/s, respectively (p < 0.01). The hfPWV also showed a strong correlation with baPWV (r = 0.698, p < 0.001). The hsCRP level was independently associated with arterial stiffness (hfPWV: R2 = 0.273, p < 0.001; baPWV: R2 = 0.284, p = 0.001) after controlling for age, body mass index, systolic blood pressure (BP), heart rate, gender, HDL-cholesterol, triglyceride, glucose level and medications. In conclusion, hsCRP was associated with arterial stiffness, independent of age, systolic BP, gender, heart rate, glucose, lipid profiles and medications in treated hypertension. Therefore, hsCRP could be a useful marker of arterial stiffness in treated hypertension patients and a possible target for arterial inflammation in hypertension.-
dc.description.statementOfResponsibilityopen-
dc.format.extent401~406-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSignificant association of C-reactive protein with arterial stiffness in treated non-diabetic hypertensive patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorTae Soo Kang-
dc.contributor.googleauthorNamsik Chung-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorHye-Sun Seo-
dc.contributor.googleauthorJin-Bae Kim-
dc.identifier.doi10.1016/j.atherosclerosis.2006.05.025-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00127-
dc.contributor.localIdA00961-
dc.contributor.localIdA01016-
dc.contributor.localIdA01042-
dc.contributor.localIdA01512-
dc.contributor.localIdA01923-
dc.contributor.localIdA03448-
dc.contributor.localIdA03585-
dc.contributor.localIdA04053-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0021915006003133-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameKim, Jin Bae-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameSeo, Hye Sun-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChung, Nam Sik-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorKim, Jin Bae-
dc.contributor.affiliatedAuthorKim, Chang Soo-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorSeo, Hye Sun-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChung, Nam Sik-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.rights.accessRightsnot free-
dc.citation.volume192-
dc.citation.number2-
dc.citation.startPage401-
dc.citation.endPage406-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.192(2) : 401-406, 2007-
dc.identifier.rimsid45014-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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