Cited 21 times in
Myocardial depressant effects of desflurane: Mechanical and electrophysiologic actions in vitro
DC Field | Value | Language |
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dc.contributor.author | 박윤곤 | - |
dc.contributor.author | 안덕선 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 채지은 | - |
dc.date.accessioned | 2014-12-21T16:23:13Z | - |
dc.date.available | 2014-12-21T16:23:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0003-3022 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95595 | - |
dc.description.abstract | BACKGROUND: The authors determined whether desflurane altered myocardial excitation-contraction coupling and electrophysiologic behavior in the same manner as isoflurane and sevoflurane. METHODS: The effects of desflurane on isometric force in guinea pig ventricular papillary muscles were studied in modified standard and in 26 mM K(+) Tyrode solution with 0.1 microm isoproterenol. Desflurane effects on sarcoplasmic reticulum Ca(2+) release were also determined by examining its actions on rat papillary muscles, guinea pig papillary muscles in low-Na(+) Tyrode solution, and rapid cooling contractures. Normal and slow action potentials were recorded using a conventional microelectrode technique. Ca(2+) and K(+) currents of guinea pig ventricular myocytes were examined. RESULTS: Desflurane (5.3% and 11.6%) decreased peak force to approximately 70% and 40% of the baseline, respectively, similar to the effects of equianesthetic isoflurane concentrations. With isoproterenol in 26 mM K(+) Tyrode solution, desflurane markedly depressed late peaking force and modestly depressed early peak force. The rested state contractions of rat myocardium or guinea pig myocardium in low-Na(+) Tyrode solution were modestly depressed, whereas rapid cooling contractures were virtually abolished after desflurane administration. Desflurane significantly prolonged the action potential duration. Desflurane reduced L-type Ca(2+) current and the delayed outward K(+) current but did not alter the inward rectifier K(+) current. CONCLUSIONS: Myocardial depression by desflurane is due to decreased Ca(2+) influx, whereas depolarization-activated sarcoplasmic reticulum Ca(2+) release is modestly depressed, similar to the actions of isoflurane and sevoflurane. Desflurane depressed the delayed outward K(+) current associated with significant lengthening of cardiac action potentials. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 956~966 | - |
dc.relation.isPartOf | ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Myocardial depressant effects of desflurane: Mechanical and electrophysiologic actions in vitro | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Wyun Kon Park | - |
dc.contributor.googleauthor | Myung Hee Kim | - |
dc.contributor.googleauthor | Carl Lynch III | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Young Seok Jee | - |
dc.contributor.googleauthor | Jee Eun Chae | - |
dc.contributor.googleauthor | Duck Sun Ahn | - |
dc.identifier.doi | 10.1097/01.anes.0000265155.01815.6d | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01593 | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A04025 | - |
dc.relation.journalcode | J00146 | - |
dc.identifier.eissn | 1528-1175 | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Chae, Jee Eun | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Chae, Jee Eun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 106 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 956 | - |
dc.citation.endPage | 966 | - |
dc.identifier.bibliographicCitation | ANESTHESIOLOGY, Vol.106(5) : 956-966, 2007 | - |
dc.identifier.rimsid | 44955 | - |
dc.type.rims | ART | - |
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