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Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery

Authors
 DONG WOO HAN  ;  SOON WON HONG  ;  KI JUN KIM  ;  JAE WOO LEE  ;  JA-YOUNG KWON 
Citation
 Acta Obstetroca et Gynecologica Scandinavica, Vol.86(6) : 683-687, 2007 
Journal Title
 Acta Obstetroca et Gynecologica Scandinavica 
ISSN
 0001-6349 
Issue Date
2007
Abstract
BACKGROUND: Postoperative pruritus, nausea, and vomiting are common side effects of intrathecal or epidural opioids. Intravenous ondansetron has been used for postoperative emesis. However, there are no reports regarding epidural ondansetron. Two studies were conducted to evaluate the prophylactic effects of epidural ondansetron for opioid-induced pruritus, nausea, and vomiting. METHODS: Neurotoxic signs were checked after epidural injection of ondansetron in rats. A clinical study was conducted to compare the prophylactic effects of epidural ondansetron with intravenous ondansetron for opioid-induced pruritus, nausea, and vomiting in cesarean delivery. RESULTS: No neurotoxic evidence was found in rats. The incidence of pruritus and nausea was significantly lower in the epidural ondansetron group than in the intravenous ondansetron group at 24 and 48 h postoperatively. CONCLUSIONS: Epidural ondansetron is more effective in preventing postoperative pruritus and nausea than intravenous ondansetron.
Full Text
http://onlinelibrary.wiley.com/doi/10.1080/00016340701302616/abstract
DOI
10.1080/00016340701302616
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Jun(김기준) ORCID logo https://orcid.org/0000-0003-1950-7998
Han, Dong Woo(한동우) ORCID logo https://orcid.org/0000-0002-8757-663X
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95519
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