Cited 7 times in
Systematic analyses of genes associated with radiosensitizing effect by celecoxib, a specific cyclooxygenase-2 inhibitor
DC Field | Value | Language |
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dc.contributor.author | 라선영 | - |
dc.contributor.author | 신유근 | - |
dc.date.accessioned | 2014-12-20T17:52:02Z | - |
dc.date.available | 2014-12-20T17:52:02Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0449-3060 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95405 | - |
dc.description.abstract | To investigate genes regulated by COX-2 or a COX-2 specific inhibitor, celecoxib, in irradiated cancer cells, we analyzed changes in gene expression using complementary DNA microarray following celecoxib or combined celecoxib and ionizing radiation (IR) treatment in a stable COX-2 knockdown A549 (AS) and a mock cell line (AN). Thirty-six genes were differentially expressed by COX-2 knockdown. Celecoxib changed the expressions of 40 and 69 genes in AN and AS cells, respectively. Twenty-seven genes were synchronously regulated by COX-2 and celecoxib. Among these, celecoxib regulated ras homolog gene family B and mitosin protein expression in a COX-2 dependent manner, especially in irradiated cells. In addition, we identified 11 genes that changed by more than 1.5 times the expected additive values after celecoxib and IR treatment. The current study may provide evidence that COX-2 or celecoxib regulates various intracellular functions in addition to their enzymatic activity regulation. We also identified candidate molecules that may be responsible for COX-2-dependent radiosensitization by celecoxib. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 752~765 | - |
dc.relation.isPartOf | JOURNAL OF RADIATION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Celecoxib | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chromosomal Proteins, Non-Histone/genetics | - |
dc.subject.MESH | Chromosomal Proteins, Non-Histone/metabolism | - |
dc.subject.MESH | Cyclooxygenase 2/deficiency | - |
dc.subject.MESH | Cyclooxygenase 2/genetics | - |
dc.subject.MESH | Cyclooxygenase 2 Inhibitors/pharmacology* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/radiation effects* | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microfilament Proteins/genetics | - |
dc.subject.MESH | Microfilament Proteins/metabolism | - |
dc.subject.MESH | Pyrazoles/pharmacology* | - |
dc.subject.MESH | RNA, Small Interfering/genetics | - |
dc.subject.MESH | Radiation Tolerance/drug effects* | - |
dc.subject.MESH | Radiation Tolerance/genetics* | - |
dc.subject.MESH | Sulfonamides/pharmacology* | - |
dc.subject.MESH | rhoB GTP-Binding Protein/genetics | - |
dc.subject.MESH | rhoB GTP-Binding Protein/metabolism | - |
dc.title | Systematic analyses of genes associated with radiosensitizing effect by celecoxib, a specific cyclooxygenase-2 inhibitor | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young-Mee KIM | - |
dc.contributor.googleauthor | You Keun SHIN | - |
dc.contributor.googleauthor | Hyun Jung JUN | - |
dc.contributor.googleauthor | Sun Young RHA | - |
dc.contributor.googleauthor | Hongryull PYO | - |
dc.identifier.doi | 10.1269/jrr.10146 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02127 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01727 | - |
dc.identifier.eissn | 1349-9157 | - |
dc.identifier.pmid | 22104269 | - |
dc.subject.keyword | COX-2 | - |
dc.subject.keyword | Celecoxib | - |
dc.subject.keyword | siRNA | - |
dc.subject.keyword | cDNAmicroarray | - |
dc.subject.keyword | Ionizing radiation | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shin, You Keun | - |
dc.contributor.affiliatedAuthor | Shin, You Keun | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 52 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 752 | - |
dc.citation.endPage | 765 | - |
dc.identifier.bibliographicCitation | JOURNAL OF RADIATION RESEARCH, Vol.52(6) : 752-765, 2011 | - |
dc.identifier.rimsid | 48347 | - |
dc.type.rims | ART | - |
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