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Pregnancy-Associated Breast Cancer Compared to Invasive Ductal Carcinoma Less Than 40 Year-Old of Age

Other Titles
 임신성 유방암과 40세 미만의 유방암과 비교 
 Ban Seok Yang  ;  Seho Park  ;  So Hee Lee  ;  Hyung Seok Park  ;  Hyewon Hwang  ;  Jun Sang Lee  ;  Si Mon Ko  ;  Seung Il Kim  ;  Byeong-Woo Park 
 Korean Journal of Clinical Oncology (대한임상종양학회지), Vol.7(2) : 28-36, 2011 
Journal Title
Korean Journal of Clinical Oncology(대한임상종양학회지)
Issue Date
Breast neoplasms ; Pregnancy ; Prognosis ; Survival
Purpose : The aims of this study were to investigate clinicopathological characteristics and outcomes of pregnancy-associated breast cancer (PABC) and to determine the implications of pregnancy itself on the prognosis of PABC.
Methods : Clinicopathological features, treatment patterns, and survival of 14 PABC patients were compared to those of 855 invasive ductal carcinoma (IDC) patients under 40 years of age, who were treated between 1987 and 2007, using a chi-square test, the Kaplan-Meier method, and Cox’s hazards models. PABC was defined as breast cancer diagnosed during pregnancy or within the first year after delivery.
Results : Among 14 PABCs, 7 were diagnosed during pregnancy and 7, during the first postpartum year. The mean duration of the symptoms was 7.6 months. The mean age at diagnosis of PABC and IDC under 40 years was 32.6 and 34.6 years, respectively (p=0.044). All PABCs were ductal type. Hormone receptors, treatment modalities, and tumor and node stage were not statistically different between PABC and IDC under 40 years. Five-year diseasefree, locoregional relapse-free, distant relapse-free, and overall survival of PABC was 57.1%, 71.3%, 56.4%, and 70.0%, respectively. Survival was not significantly different between two groups. In Cox°Øs models, PABC was not associated with survival outcomes. Among PABCs, there was no statistical difference in survival between patients diagnosed before and after delivery.
Conclusion : Pregnancy itself does not increase the risk of poorer outcomes among young breast cancer patients. Vigilant diagnosis and multidisciplinary treatment should be recommended to best manage woman with PABC and her baby.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ko, Si Mon(고시몬)
Kim, Seung Il(김승일)
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Park, Hyung Seok(박형석) ORCID logo https://orcid.org/0000-0001-5322-6036
Lee, So Hee(이소희)
Lee, Jun Sang(이준상) ORCID logo https://orcid.org/0000-0002-4054-6900
Hwang, Hye Won(황혜원)
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