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Statins inhibit chemotactic interaction between CCL20 and CCR6 in vitro: possible relevance to psoriasis treatment

Authors
 Tae-Gyun Kim  ;  Dashlkhumbe Byamba  ;  Wen Hao Wu  ;  Min-Geol Lee 
Citation
 EXPERIMENTAL DERMATOLOGY, Vol.20(10) : 855-857, 2011 
Journal Title
EXPERIMENTAL DERMATOLOGY
ISSN
 0906-6705 
Issue Date
2011
MeSH
Cell Line ; Cell Migration Inhibition/drug effects ; Cell Migration Inhibition/immunology ; Chemokine CCL20/metabolism* ; Chemotaxis/drug effects* ; Chemotaxis/immunology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology* ; Interleukin-17/pharmacology ; Interleukin-1beta/pharmacology ; Keratinocytes/drug effects ; Keratinocytes/immunology ; Psoriasis/drug therapy* ; Psoriasis/immunology ; Receptors, CCR6/metabolism* ; Tumor Necrosis Factor-alpha/pharmacology
Keywords
CCL20 ; CCR6 ; IL-23/Th17 axis ; psoriasis ; statins
Abstract
Psoriasis is a chronic IL-23/Th17 pathway-associated skin disease. An increased expression of lesional CCL20 can recruit CCR6+ Th17, and lesional cytokine milieu persistently activates keratinocytes to produce CCL20. Lipid-lowering drugs, statins, are known to possess immune-modulating functions. In this study, we explored an inhibitory effect of statins on CCL20/CCR6 interaction. We demonstrated that IL-1β, TNF-α, and IL-17A significantly increased CCL20 production from HaCaT cells. However, these increments were markedly inhibited by fluvastatin and simvastatin, but not by pravastatin. In the chemotaxis migration assay, pretreatment with fluvastatin and simvastatin inhibited the migration of human CD4+ T cells towards CCL20. However, the level of CCR6 surface expression in memory CD4+ T cells was not affected. Our results suggest that not all, but specific types of statins may be of benefit in alleviating psoriasis partially via interrupting CCL20/CCR6 chemotactic interaction, the mechanism which may eventually lessen the infiltration of Th17 cells.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2011.01343.x/abstract
DOI
10.1111/j.1600-0625.2011.01343.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Gyun(김태균) ORCID logo https://orcid.org/0000-0002-2116-4579
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95218
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