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Prognosis of gingival squamous cell carcinoma diagnosed after invasive procedures

Authors
 Eun-Joo Choi  ;  Xianglan Zhang  ;  Hyung-Jun Kim  ;  Woong Nam  ;  In-Ho Cha 
Citation
 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol.12(10) : 2649-2652, 2011 
Journal Title
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
ISSN
 1513-7368 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/mortality* ; Carcinoma, Squamous Cell/therapy ; Female ; Gingival Neoplasms/diagnosis ; Gingival Neoplasms/mortality* ; Gingival Neoplasms/therapy ; Humans ; Lymphatic Metastasis/pathology ; Male ; Mandibular Neoplasms/secondary ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Osteomyelitis/diagnosis ; Periodontitis/diagnosis ; Retrospective Studies ; Survival Rate ; Treatment Outcome
Keywords
Squamous Cell Carcinoma ; Surgery ; mandibular neoplasms ; maxillary neopla는
Abstract
Gingival squamous cell carcinoma (SCC) has a relatively poor prognosis, because differential diagnoses of periodontitis and osteomyelitis are difficult to exclude. As such, gingival SCC is usually diagnosed late, following invasive procedures such as extraction or curettage. The purpose of this study was to classify gingival SCC patients into two groups according to the location of their primary lesion: dentate and edentulous, and to determine the appropriate treatment strategy by comparing clinical and histological features as well as treatment results. The medical records of 76 patients diagnosed with gingival SCC and treated at one institute from 1 January 1993 to 31 December 2007 were reviewed. The overall 5-year survival rate was 60.7%, and the mean survival was 98 months. Factors affecting survival included bone invasion of the primary lesion (p = 0.035), neck node metastasis (p = 0.001), and local recurrence (p = 0.000). The results suggest that more aggressive treatment, such as setting a broad surgical field and enforcing preventive neck dissection, can improve outcome, although they are associated with increased rate of cancer bone invasion and neck metastasis in patients diagnosed with cancer after receiving invasive procedures.
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Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
Nam, Woong(남웅) ORCID logo https://orcid.org/0000-0003-0146-3624
Zhang, Xiang Lan(장향란)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Choi, Eyn Joo(최은주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95194
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