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Efficacy of oxaliplatin-based chemotherapy in curatively resected colorectal cancer with liver metastasis

Authors
 Kim H.R.  ;  Min B.S.  ;  Kim J.S.  ;  Shin S.J.  ;  Ahn J.B.  ;  Rho J.K.  ;  Kim N.K.  ;  Rha S.Y 
Citation
 ONCOLOGY, Vol.81(3-4) : 175-183, 2011 
Journal Title
ONCOLOGY
ISSN
 0030-2414 
Issue Date
2011
MeSH
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy* ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/secondary ; Colorectal Neoplasms/surgery* ; Disease-Free Survival ; Female ; Fluorouracil/administration & dosage ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Liver Neoplasms/drug therapy* ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Metastasis ; Organoplatinum Compounds/administration & dosage ; Organoplatinum Compounds/adverse effects ; Prognosis ; Retrospective Studies ; Survival Rate
Keywords
Adjuvant chemotherapy ; Colorectal neoplasms ; Liver metastasis ; Oxaliplatin
Abstract
OBJECTIVES: Although surgical resection alone has been validated as a standard treatment for patients with liver metastases from colorectal cancer, a high rate of recurrence is still an issue to be overcome. We aimed to assess the efficacy of adjuvant chemotherapy using an oxaliplatin-based regimen in patients who underwent hepatic and primary colorectal cancer resection.

METHODS: Sixty patients who received oxaliplatin-based postoperative chemotherapy combined with curative resection of primary colorectal cancer and synchronous liver metastases between January 2000 and February 2008 were retrospectively reviewed. The Kaplan-Meier method was used to estimate survival, and prognostic factors were evaluated with the log-rank test.

RESULTS: Median overall survival (OS) was 62.8 months [95% confidence interval (CI) 44.1-81.3], and median relapse-free survival (RFS) was 32.8 months (95% CI 5.8-59.6). The 1-, 3- and 5-year survival rates were 95.0, 68.8 and 55.5%, respectively. The relapse-free interval and modality of liver resection were independently associated with OS.

CONCLUSIONS: Oxaliplatin-based adjuvant chemotherapy after radical resection resulted in increased OS and RFS with acceptable tolerability compared to surgery alone. However, it is not yet clear whether postoperative oxaliplatin-based chemotherapy improves outcome compared to patients treated with 5-fluorouracil plus leucovorin.
Full Text
http://www.karger.com/Article/FullText/333440
DOI
10.1159/000333440
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Jin Soo(김진수)
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Shin, Sang Joon(신상준) ORCID logo https://orcid.org/0000-0001-5350-7241
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95047
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