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Efficacy of oxaliplatin-based chemotherapy in curatively resected colorectal cancer with liver metastasis

Authors
 Kim H.R.  ;  Min B.S.  ;  Rha S.Y  ;  Kim N.K.  ;  Rho J.K.  ;  Ahn J.B.  ;  Shin S.J.  ;  Kim J.S. 
Citation
 Oncology, Vol.81(3-4) : 175-183, 2011 
Journal Title
 Oncology 
ISSN
 0030-2414 
Issue Date
2011
Abstract
OBJECTIVES: Although surgical resection alone has been validated as a standard treatment for patients with liver metastases from colorectal cancer, a high rate of recurrence is still an issue to be overcome. We aimed to assess the efficacy of adjuvant chemotherapy using an oxaliplatin-based regimen in patients who underwent hepatic and primary colorectal cancer resection. METHODS: Sixty patients who received oxaliplatin-based postoperative chemotherapy combined with curative resection of primary colorectal cancer and synchronous liver metastases between January 2000 and February 2008 were retrospectively reviewed. The Kaplan-Meier method was used to estimate survival, and prognostic factors were evaluated with the log-rank test. RESULTS: Median overall survival (OS) was 62.8 months [95% confidence interval (CI) 44.1-81.3], and median relapse-free survival (RFS) was 32.8 months (95% CI 5.8-59.6). The 1-, 3- and 5-year survival rates were 95.0, 68.8 and 55.5%, respectively. The relapse-free interval and modality of liver resection were independently associated with OS. CONCLUSIONS: Oxaliplatin-based adjuvant chemotherapy after radical resection resulted in increased OS and RFS with acceptable tolerability compared to surgery alone. However, it is not yet clear whether postoperative oxaliplatin-based chemotherapy improves outcome compared to patients treated with 5-fluorouracil plus leucovorin.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/95047
DOI
10.1159/000333440
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김남규(Kim, Nam Kyu) ; 김진수(Kim, Jin Soo) ; 김혜련(Kim, Hye Ryun) ; 노재경(Roh, Jae Kyung) ; 라선영(Rha, Sun Young) ; 민병소(Min, Byung Soh) ; 신상준(Shin, Sang Joon) ; 안중배(Ahn, Joong Bae)
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http://www.karger.com/Article/FullText/333440
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