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Delta neutrophil index as an early marker of disease severity in critically ill patients with sepsis

 Byung Hoon Park  ;  Young Ae Kang  ;  Young Sam Kim  ;  Ji Ye Jung  ;  Joon Chang  ;  Se Kyu Kim  ;  Song Yee Kim  ;  Sang Kook Lee  ;  Su Hwan Lee  ;  Won Jai Jung  ;  Moo Suk Park 
 BMC Infectious Diseases, Vol.11 : 299-299, 2011 
Journal Title
 BMC Infectious Diseases 
Issue Date
BACKGROUND: The immature granulocyte count has been reported to be a marker of infection and sepsis. The difference in leukocyte subfractions (delta neutrophil index, DNI) in ADVIA 2120 reflects the fraction of circulating immature granulocytes in the blood. This study evaluated the clinical utility of DNI as a severity and prediction marker in critically ill patients with sepsis. METHODS: One hundred and three patients admitted to the medical intensive care unit with sepsis were studied. DNI (the difference in leukocyte subfractions identified by myeloperoxidase and nuclear lobularity channels) was determined using a specific blood cell analyzer. RESULTS: Forty four patients (42.7%) were diagnosed with severe sepsis/septic shock. Overt disseminated intravascular coagulation (DIC) occurred in 40 (38.8%). DNI was significantly higher in patients with severe sepsis/septic shock and overt DIC than in patients without (p < 0.05). DNI correlated with DIC score (r = 0.54, p < 0.001). We observed a monotonic increase in the proportion of overt DIC and severe sepsis/septic shock associated with increasing quartiles of DNI (p < 0.001). A DNI value > 6.5% was a better indicator of severe sepsis/septic shock than C-reactive protein, lactate, white blood cell count, and absolute neutrophil count (sensitivity, 81.3%; specificity, 91.0%; positive predictive value, 88.6%; and negative predictive value, 84.7%). In 36 (82%) of the 44 patients with severe sepsis/septic shock, DNI values were already elevated up to 12 hours before the onset of organ/circulatory failure. CONCLUSIONS: DNI may be used as a marker of disease severity in critically ill patients with sepsis. High levels of DNI may help to identify patients with an impending risk of developing severe sepsis/septic shock.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강영애(Kang, Young Ae) ; 김세규(Kim, Se Kyu) ; 김송이(Kim, Song Yi) ; 김영삼(Kim, Young Sam) ; 박무석(Park, Moo Suk) ; 박병훈(Park, Byung Hoon) ; 이상국(Lee, Sang Kook) ; 이수환(Lee, Su Whan) ; 장준(Chang, Joon) ; 정원재(Jung, Won Jai) ; 정지예(Jung, Ji Ye)
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