Cited 27 times in
MMP-2 as a putative biomarker for carcinomatosis in gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박찬희 | - |
dc.contributor.author | 정민규 | - |
dc.contributor.author | 정재준 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 정희철 | - |
dc.contributor.author | 노세원 | - |
dc.date.accessioned | 2014-12-20T17:39:14Z | - |
dc.date.available | 2014-12-20T17:39:14Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0172-6390 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95008 | - |
dc.description.abstract | BACKGROUND/AIMS: We evaluated matrix metalloproteinase (MMP)-2 and -9 as novel biomarkers in the body fluid of advanced gastric cancer with peritoneal and pulmonary metastasis. METHODOLOGY: MMPs activity from zymography was quantified with ELISA to determine the cut-off expression levels of MMPs. The expression of MMPs in patient samples were evaluated with ELISA and compared with clinical parameters. Ascitic CEA (aCEA) and pleural CEA (pCEA) were measured by chemiluminescent enzyme immunoassay. RESULTS: MMP-2 and -9 cut-off levels were 8.6ng/mL and 0.14ng/mL, respectively. Ascitic fluid cytology of 93 patients revealed a positivity of 55.9% while for MMP-2 it was 93.3%, for MMP-9 35.2% and for aCEA 86.7%. Combining biomarkers, the positivity increased to 99.1% in patients with MMP-2 or aCEA expression. We found a negative correlation between MMP-2 expression and survival when a new prognostic cut-off of 22.6ng/mL was used. Patients with high MMP-2 expression (≥22.6ng/mL) had a median survival of 45 days and those with low MMP-2 expression (<22.6ng/mL) had a median survival of 69 days (p<0.01). CONCLUSIONS: These results suggest that MMPs could be used as diagnostic markers in body fluid and MMP-2 might be a prognostic marker in ascites of advanced gastric patients with disseminated metastasis. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | HEPATO-GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Carcinoembryonic Antigen/analysis | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 2/analysis* | - |
dc.subject.MESH | Matrix Metalloproteinase 2/physiology | - |
dc.subject.MESH | Matrix Metalloproteinase 9/analysis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Stomach Neoplasms/diagnosis* | - |
dc.subject.MESH | Stomach Neoplasms/enzymology | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.title | MMP-2 as a putative biomarker for carcinomatosis in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Noh S | - |
dc.contributor.googleauthor | Jung JJ | - |
dc.contributor.googleauthor | Jung M | - |
dc.contributor.googleauthor | Kim TS | - |
dc.contributor.googleauthor | Park CH | - |
dc.contributor.googleauthor | Lim SJ | - |
dc.contributor.googleauthor | Jeung HC | - |
dc.contributor.googleauthor | Cheol H | - |
dc.contributor.googleauthor | Chung HC | - |
dc.contributor.googleauthor | Rha SY | - |
dc.identifier.doi | 10.5754/hge11209 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01712 | - |
dc.contributor.localId | A03606 | - |
dc.contributor.localId | A03773 | - |
dc.contributor.localId | A01282 | - |
dc.contributor.localId | A03794 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00984 | - |
dc.identifier.pmid | 22024074 | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Chan Hee | - |
dc.contributor.alternativeName | Jung, Min Kyu | - |
dc.contributor.alternativeName | Jung, Jae Joon | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.alternativeName | Jeung, Hei Cheul | - |
dc.contributor.alternativeName | Noh, Se Won | - |
dc.contributor.affiliatedAuthor | Park, Chan Hee | - |
dc.contributor.affiliatedAuthor | Jung, Min Kyu | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Noh, Se Won | - |
dc.contributor.affiliatedAuthor | Jeung, Hei Cheul | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 58 | - |
dc.citation.number | 112 | - |
dc.citation.startPage | 2015 | - |
dc.citation.endPage | 2019 | - |
dc.identifier.bibliographicCitation | HEPATO-GASTROENTEROLOGY, Vol.58(112) : 2015-2019, 2011 | - |
dc.identifier.rimsid | 26977 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.