Cited 4 times in
Role of regulators of g-protein signaling 4 in ca signaling in mouse pancreatic acinar cells
DC Field | Value | Language |
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dc.contributor.author | 이승일 | - |
dc.contributor.author | 박순홍 | - |
dc.contributor.author | 신동민 | - |
dc.date.accessioned | 2014-12-20T17:37:19Z | - |
dc.date.available | 2014-12-20T17:37:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94949 | - |
dc.description.abstract | Regulators of G-protein signaling (RGS) proteins are regulators of Ca(2+) signaling that accelerate the GTPase activity of the G-protein α-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas, and RGS2 regulates G-protein coupled receptor (GPCR)-induced Ca(2+) oscillations. However, the role of RGS4 in Ca(2+) signaling in pancreatic acinar cells is unknown. In this study, we investigated the mechanism of GPCR-induced Ca(2+) signaling in pancreatic acinar cells derived from RGS4(-/-) mice. RGS4(-/-) acinar cells showed an enhanced stimulus intensity response to a muscarinic receptor agonist in pancreatic acinar cells. Moreover, deletion of RGS4 increased the frequency of Ca(2+) oscillations. RGS4(-/-) cells also showed increased expression of sarco/endoplasmic reticulum Ca(2+) ATPase type 2. However, there were no significant alterations, such as Ca(2+) signaling in treated high dose of agonist and its related amylase secretion activity, in acinar cells from RGS4(-/-) mice. These results indicate that RGS4 protein regulates Ca(2+) signaling in mouse pancreatic acinar cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 383~388 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Role of regulators of g-protein signaling 4 in ca signaling in mouse pancreatic acinar cells | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Soonhong Park | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Dong Min Shin | - |
dc.identifier.doi | 10.4196/kjpp.2011.15.6.383 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02924 | - |
dc.contributor.localId | A01547 | - |
dc.contributor.localId | A02091 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.identifier.pmid | 22359476 | - |
dc.subject.keyword | RGS4 | - |
dc.subject.keyword | Ca2+ signaling | - |
dc.subject.keyword | Pancreatic acinar cells | - |
dc.contributor.alternativeName | Lee, Syng Ill | - |
dc.contributor.alternativeName | Park, Soon Hong | - |
dc.contributor.alternativeName | Shin, Dong Min | - |
dc.contributor.affiliatedAuthor | Lee, Syng Ill | - |
dc.contributor.affiliatedAuthor | Park, Soon Hong | - |
dc.contributor.affiliatedAuthor | Shin, Dong Min | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 383 | - |
dc.citation.endPage | 388 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.15(6) : 383-388, 2011 | - |
dc.identifier.rimsid | 26942 | - |
dc.type.rims | ART | - |
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