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Immunoglobulin G4-related hypertrophic pachymeningitis involving cerebral parenchyma.

Authors
 Eui Hyun Kim  ;  Se Hoon Kim  ;  Jin Mo Cho  ;  Jung Yong Ahn  ;  Jong Hee Chang 
Citation
 JOURNAL OF NEUROSURGERY, Vol.115(6) : 1242-1247, 2011 
Journal Title
JOURNAL OF NEUROSURGERY
ISSN
 0022-3085 
Issue Date
2011
MeSH
Adrenal Cortex Hormones/therapeutic use ; Adult ; Diagnosis, Differential ; Dura Mater/immunology* ; Dura Mater/metabolism ; Dura Mater/pathology* ; Humans ; Hypertrophy/drug therapy ; Hypertrophy/immunology ; Hypertrophy/pathology ; Hypertrophy/surgery ; Immunoglobulin G/immunology* ; Immunoglobulin G/metabolism ; Immunohistochemistry ; Male ; Meningitis/drug therapy ; Meningitis/immunology* ; Meningitis/pathology* ; Meningitis/surgery ; Remission Induction
Keywords
cerebral parenchymal involvement ; infection ; immunoglobulin G4–related disease ; meningioma-mimicking lesion ; nodular type of hypertrophic pachymeningitis
Abstract
The authors report a case of IgG4-related hypertrophic pachymeningitis that involved cerebral parenchyma. The mass was removed surgically. Histopathological studies showed diffuse infiltration of lymphoplasmacytic cells without evidence of Langerhans histiocytes or meningothelial cells. Immunoglobulin G4 was strongly positive on immunohistochemical staining. The Gd-enhanced lesion deep inside brain parenchyma was completely resolved after 3 months of oral corticosteroid medication. A nodular type of hypertrophic pachymeningitis that mimics a meningioma is rare. Nevertheless, preoperative presumption is very important, and immunohistochemical studies for IgG4 may be helpful in the differential diagnosis.
Full Text
http://thejns.org/doi/full/10.3171/2011.7.JNS1166
DOI
10.3171/2011.7.JNS1166
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Eui Hyun(김의현) ORCID logo https://orcid.org/0000-0002-2523-7122
Ahn, Jung Yong(안정용)
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94799
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