270 647

Cited 47 times in

Key role for IL-21 in experimental autoimmune uveitis

Authors
 Lu Wang  ;  Cheng-Rong Yu  ;  Hyoung-Pyo Kim  ;  Wei Liao  ;  William G. Telford  ;  Charles E. Egwuagu  ;  Warren J. Leonard 
Citation
 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.108(23) : 9542-9547, 2011 
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN
 0027-8424 
Issue Date
2011
MeSH
Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology* ; Autoimmune Diseases/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Cells, Cultured ; Flow Cytometry ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Interleukin-17/immunology ; Interleukin-17/metabolism ; Interleukin-1beta/immunology ; Interleukin-1beta/metabolism ; Interleukin-2/genetics ; Interleukin-2/immunology* ; Interleukin-2/metabolism ; Interleukin-6/immunology ; Interleukin-6/metabolism ; Interleukins/genetics ; Interleukins/immunology* ; Interleukins/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptors, Interleukin-21/genetics ; Receptors, Interleukin-21/immunology ; Receptors, Interleukin-21/metabolism ; Retina/metabolism ; Retina/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Uveitis/genetics ; Uveitis/immunology* ; Uveitis/metabolism
Abstract
IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas IL-2 promotes development of regulatory T cells and confers protection from autoimmune disease, IL-21 promotes differentiation of Th17 cells and is implicated in several autoimmune diseases, including type 1 diabetes and systemic lupus erythematosus. However, the roles of IL-21 and IL-2 in CNS autoimmune diseases such as multiple sclerosis and uveitis have been controversial. Here, we generated Il21-mCherry/Il2-emGFP dual-reporter transgenic mice and showed that development of experimental autoimmune uveitis (EAU) correlated with the presence of T cells coexpressing IL-21 and IL-2 into the retina. Furthermore, Il21r(-/-) mice were more resistant to EAU development than wild-type mice, and adoptive transfer of Il21r(-/-) T cells induced much less severe EAU, underscoring the need for IL-21 in the development of this disease and suggesting that blocking IL-21/γ(c)-signaling pathways may provide a means for controlling CNS auto-inflammatory diseases.
Files in This Item:
T201104715.pdf Download
DOI
10.1073/pnas.1018182108
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94785
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links