Cited 55 times in
Differentially expressed microRNAs in pancreatic cancer stem cells
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.contributor.author | 정다운 | - |
dc.date.accessioned | 2014-12-20T17:31:27Z | - |
dc.date.available | 2014-12-20T17:31:27Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0885-3177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94759 | - |
dc.description.abstract | OBJECTIVE: The objective of this study was to analyze and identify pancreatic cancer stem cell-specific microRNAs (miRNAs) and messenger RNAs (mRNAs) to investigate their correlations to cancer stem cell biology. METHODS: We used sphere cultivation methods to enrich the stem cell population and analyzed overall miRNA and mRNA expressions using microarray analysis. RESULTS: Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells. Furthermore, examining both profiles, we obtained 210 miRNAs and 258 stem cell-associated mRNAs that were differentially expressed in the pancreatic cancer stem cells. These miRNAs and mRNAs were further investigated using cross-correlation analysis, which yielded 6 groups of miRNAs and 3 groups of mRNAs. The number of miRNA clusters and mRNA clusters showed high correlation based on microarray result. CONCLUSIONS: Differentially expressed miRNAs in pancreatic cancer stem cells provide insights into possible linkages between clusters of miRNAs and clusters of stem cell-associated mRNAs in cancer stem cells and have broad implications in our understanding of cancer stem cells and cancer stem cell-targeted cancer therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1180~1187 | - |
dc.relation.isPartOf | PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cluster Analysis | - |
dc.subject.MESH | Gene Expression Profiling* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | MicroRNAs/genetics* | - |
dc.subject.MESH | Neoplastic Stem Cells/metabolism* | - |
dc.subject.MESH | Neoplastic Stem Cells/pathology | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.subject.MESH | Pancreatic Neoplasms/genetics | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Spheroids, Cellular/metabolism | - |
dc.subject.MESH | Spheroids, Cellular/pathology | - |
dc.title | Differentially expressed microRNAs in pancreatic cancer stem cells | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute of Gastroenterology (소화기병연구소) | - |
dc.contributor.googleauthor | Jung, Dawoon E. | - |
dc.contributor.googleauthor | Wen, Jing | - |
dc.contributor.googleauthor | Oh, Taeyun | - |
dc.contributor.googleauthor | Song, Si Young | - |
dc.identifier.doi | 10.1097/MPA.0b013e318221b33e | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03587 | - |
dc.relation.journalcode | J02463 | - |
dc.identifier.eissn | 1536-4828 | - |
dc.identifier.pmid | 21785383 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201111000-00004&LSLINK=80&D=ovft | - |
dc.subject.keyword | simple bone cyst | - |
dc.subject.keyword | conservative management | - |
dc.subject.keyword | observation | - |
dc.subject.keyword | steroid injection | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Jung, Dawoon E. | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Jung, Dawoon E. | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1180 | - |
dc.citation.endPage | 1187 | - |
dc.identifier.bibliographicCitation | PANCREAS, Vol.40(8) : 1180-1187, 2011 | - |
dc.identifier.rimsid | 27730 | - |
dc.type.rims | ART | - |
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